Anabolic Steroids - Topic OverviewAndrogenic steroids are used for male sex hormone replacement and in the therapy of malignancies. The androgens also have anabolic effects and are used in catabolic or muscle wasting states. Abuse of anabolic steroids liver synthetic anabolic steroids are also widely used illicitly for body building. Many synthetic androgenic steroids are capable of causing cholestatic liver injury and long term use of androgens is associated with development of liver tumors including hepatocellular carcinoma and abuse of anabolic steroids liver adenoma. Testosterone is the major male sex hormone stroids is produced wbuse the male testes in men and to a lesser extent by the adrenal glands in both men mersul trenurilor ungheni balti women.
Anabolic androgenic steroids abuse and liver toxicity. - PubMed - NCBI
Anabolic steroid abuse is common among athletes and is associated with a number of medical complications. We describe a case of a year-old male bodybuilder with multiple hepatic adenomas induced by anabolic steroids. He initially presented with tumor hemorrhage and was treated with left lateral hepatic segmentectomy. Regression of the remaining tumors was observed with cessation of steroid use.
However, 3 years and a half after his initial hepatic segmentectomy, he presented with recurrent tumor enlargement and intraperitoneal hemorrhage in the setting of steroid abuse relapse.
Given his limited hepatic reserve, he was conservatively managed with embolization of the right accessory hepatic artery. This is the first reported case of hepatic adenoma re-growth with recidivistic steroid abuse, complicated by life-threatening hemorrhage.
While athletes and bodybuilders are often aware of the legal and social ramifications of steroid abuse, they should continue to be counseled about its serious medical risks. Anabolic steroid abuse is common among athletes and is associated with a number of medical complications[ 1 — 3 ].
Reported hepatic complications include cholestasis, elevation of aminotransferases, jaundice, benign hepatic adenomas, and rare cases of hepatocellular carcinoma[ 4 — 6 ]. Histologic findings include peliosis hepatis, a lesion characterized by hepatic sinusoidal dilatation that is often cystic[ 7 , 8 ].
Rupture of these cysts can cause fatal internal hemorrhage[ 9 ]. We report the first case of adenoma re-growth and hemorrhage after relapse of androgen abuse.
A year-old man with a 5-year history of anabolic steroid abuse presented to the emergency room with 2 d of midepigastric pain and nausea. His only medications were oral androstenedione and intramuscular nandrolone. He was a police officer and competitive bodybuilder. He denied use of alcohol, tobacco, and intravenous drugs. Physical examination disclosed midepigastric tenderness and tender hepatomegaly. Laboratories were notable for 2. Abdominal computed tomography CT on admission showed a round, heterogeneous-appearing 9.
Magnetic resonance imaging MRI with gadolinium contrast demonstrated multiple hepatic masses, the largest of which measured The patient underwent left lateral hepatic segmentectomy with open cholecystectomy. Pathologic examination revealed an adenoma with peliosis hepatis, 25 cm in diameter. The patient was instructed to discontinue steroid use. The patient subsequently resumed oral androstenedione only.
T1-weighted magnetic resonance imaging MRI of multiple hepatic adenomas. MRI at initial presentation demonstrates a heterogeneous-appearing, well-circumscribed mass measuring The largest mass has an enhancing capsule and demonstrates areas of internal T1 hyperintensity and hypointensity, as well as T2 hyperintensity, characteristic of an adenoma with intralesional hemorrhage; B: Images have been electronically adjusted to illustrate lesions.
Approximately 3 years and a half after his first presentation, the patient returned to the emergency room with sudden-onset, right-upper quadrant pain in the setting of recurrent injection nandrolone use 6 wk earlier.
Vital signs were within normal limits, and there was tender hepatomegaly. Prothrombin time PT was The hematocrit was Abdominal CT revealed several lesions in the right lobe of the liver, the largest of which had increased in size to 7. CT angiogram on hospital day 2 showed no contrast extravasation, but the hematocrit dropped to On hospital day 3, the right upper quadrant pain worsened, and he became tachycardic. Because of his limited hepatic reserve and ongoing steroid abuse, he was felt to be a poor candidate for either hepatic resection or liver transplantation.
He, therefore, underwent angiographic embolization of the accessory right hepatic artery. Four units of packed red blood cells were transfused. After transient oliguric renal failure, he was discharged to home on post-procedural day 5. Abdominal CT at second presentation with abdominal pain after resumption of steroid abuse. A heterogeneous-appearing, right hepatic mass measuring 7. Image has been electronically altered.
We report a rare case of hepatic adenoma regrowth with recidivistic steroid abuse, complicated by life-threatening hemorrhage. This case underscores the potentially life-threatening complications of anabolic steroid abuse, and calls for a high index of suspicion among health care providers for hepatic complications if a history of steroid use is elicited.
The risk of androgen-associated liver tumors appears to correlate with the cumulative androgen dose and the potency of the steroid used[ 10 ]. Our patient self-administered both oral androstenedione, which has relatively weak androgenic potential, and parenteral nandrolone, which is particularly potent due to C10 hydroxylation. Since androstenedione has not been associated with liver tumors, it is likely that the nandrolone promoted development of his hepatic adenomas.
This is consistent with the recurrence of his symptoms soon after resumption of nandrolone. Both nandrolone and androstenedione have been classified as Schedule III controlled substances in recognition of their abuse potential[ 11 , 12 ]. Despite these legal restrictions, anyone can still obtain these drugs with little difficulty over the Internet.
By resuming anabolic steroid consumption after his first hospitalization, our patient clearly demonstrated a pattern of substance abuse. Risk factors for anabolic steroid abuse in male bodybuilders include body-image disturbances, history of childhood conduct disorder, and poor father-son relationships[ 13 ]. Patients and physicians must be reminded that the sequelae of anabolic steroid abuse are life threatening. While athletes and bodybuilders are often aware of the legal and social ramifications of steroid abuse, they should also be counseled about its serious medical risks.
In the context of an addictive behavior pattern, assiduous surveillance for neoplasms should also be undertaken. The authors would like to thank Andrew Loiacono, MD, for his interpretations of the radiologic images.
National Center for Biotechnology Information , U. Journal List World J Gastroenterol v. Published online Jul This article has been cited by other articles in PMC. Abstract Anabolic steroid abuse is common among athletes and is associated with a number of medical complications. Anabolic steroids, Adenoma, Liver, Hemorrhage. Open in a separate window. Acknowledgments The authors would like to thank Andrew Loiacono, MD, for his interpretations of the radiologic images.
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