Tetrahydrogestrinone (THG)This monograph test 400 tren and winny cycle intended for informational purposes only, and should not be interpreted as specific medical advice. This legislation was passed in response to a growing illegal market anabolic steroid thg effect due to concerns about the possible harmful long-term effects of steroid use. Anabolic steroids are synthetic male sex hormones, collectively anabolic steroid thg effect as androgens. Although banned in sporting events, athletes frequently take these hormones to build more muscle and provide enhanced endurance. Some anabolic-androgenic steroids, such as methyltestosterone, oxandrolone, and oxymetholone have approved medical uses, but tetrahydrogestrinone THG does not. It is commonly referred to as a "designer drug" because it is specifically formulated to be undetectable in drug tests. Athletes are regularly screened for such illegal methods in professional sports and the Olympics.
Tetrahydrogestrinone - Wikipedia
Tetrahydrogestrinone THG , known by the nickname The Clear , is a synthetic and orally active anabolic—androgenic steroid AAS which was never marketed for medical use. THG was developed completely in secret by Arnold as a designer drug , on the basis that doping testers would be unlikely to detect a totally new compound.
Arnold developed a chemical similar to two obscure steroids marketed by BALCO, norbolethone and desoxymethyltestosterone , which had been reported in scientific literature but never entered mass production, and the banned anabolic steroids trenbolone and gestrinone , the latter of which was used to synthesize it. In , whistleblower Trevor Graham passed a spent syringe containing a small amount of the drug to the United States Anti-Doping Agency. This was then transferred to the research group of pharmacologist Don Catlin , who identified the drug using mass spectrometry techniques and gave it its present name.
THG has never been fully tested for safety and has never entered legitimate medical use, although some studies have been made of its properties. Side effects from prolonged use are likely to include infertility in both men and women, as well as other steroid side effects such as acne and hirsutism. It has been found to bind to the androgen receptor with similar affinity to dihydrotestosterone and produces growth of muscle tissue. When THG reaches the nucleus of a cell, it binds to the androgen receptor at the ligand-binding pocket.
Here it changes the expression of a variety of genes, turning on several anabolic and androgenic functions. Even minor modifications in the ligand's structure have a great impact on the strength of the interactions this ligand has with the androgen receptor.
THG, possessing a high affinity, establishes more van der Waals contacts with the receptor than with many other steroids. For a time, THG was considered the drug of choice for safe and "invisible" world record breaking in athletics, being used by several high-profile gold medal winners such as the sprinter Marion Jones , who resigned from her athletic career in after admitting to using THG prior to the Sydney Olympics , where she had won three gold medals.
From Wikipedia, the free encyclopedia. Retrieved 3 September Don Catlin on Anti-Doping in Boxing". Rapid Communications in Mass Spectrometry. Strasburger 28 October Hormone Use and Abuse by Athletes. Retrieved May 25, Archived from the original on Cortisol-like and related unsubstituted: Retrieved from " https: Views Read Edit View history.