Anabolic Steroid AbuseHypersecretion of endogenous hormones or chronic administration of high doses of the same hormones induces wihtdrawal degrees of tolerance and dependence. Elimination of hormone hypersecretion or discontinuation of hormone therapy may result in a mixed picture of two syndromes: Thus, hormones anabolic steroid withdrawal psychosis completely different physiological ace tren trenbolone may produce similar withdrawal syndromes, with symptoms and signs reminiscent of those observed with drugs of abuse, suggesting shared mechanisms. This review postulates a unified endocrine withdrawal syndrome, with changes in the hypothalamic-pituitary-adrenal axis and the central opioid peptide, in which noradrenergic and dopaminergic systems of the brain act as common links in its ppsychosis. Long-term adaptations to hormones may involve relatively persistent changes in molecular switches, including common anabolic steroid withdrawal psychosis signaling systems, from membrane receptors to transcription factors.
Steroid Abuse: Read About Signs, Statistics & Treatment
We've noticed that you're using an ad blocker Our content is brought to you free of charge because of the support of our advertisers. To continue enjoying our content, please turn off your ad blocker. Behavioral manifestations of anabolic steroid use. Anabolic steroids have gone from an appropriate treatment for men with hypogonadism to an agent abused by athletes, bodybuilders, adolescents, and young adults.
Use of steroids at levels 10 to times those of therapeutic dosages can cause psychiatric symptoms, such as aggression, mania, depression, and psychosis.
Steroid abusers often "stack" several steroids or "pyramid" agents through a 4- to week cycle. Presenting complaints of steroid abusers include muscle spasms, dizziness, frequent urination, and menstrual abnormalities. Signs may include high blood pressure, needle marks, icteric eyes, muscle hypertrophy, and edema; testicular atrophy and gynecomastia in men; and hirsutism and atrophied breasts in women. Mood changes can occur within a week of first use, and body changes may occur after acute behavioral disturbances.
Persons who discontinue steroid use may have withdrawal symptoms, such as fatigue, anorexia, headaches, muscle and joint pain, decreased libido, and depression.
Some experience suicidal ideation in connection with withdrawal. Acute therapy may be needed for agitation, mania, or psychosis with medications such as antipsychotic agents, benzodiazepines, or valproate.
Human chorionic gonadotropin can aid in returning the hypothalamic-pituitary-gonadal axis to normal functioning. You hardly need to change television channels to be informed about the latest scandal involving anabolic steroids. This is certainly a "hot" topic. As this excellent review exemplifies, it is surprising in light of the significance of and public interest in this topic how little is known about steroid abuse and its psychiatric sequelae.
Many recurrent themes are well articulated in this review. Do steroids make persons prone to violence, or are already violent persons more likely to take these agents? A similar question could be asked regarding the possible relationship between steroid use and suicidality. With bipolar disorder particularly bipolar depression now a more frequent consideration, the relationship between mood disturbances and steroid abuse seems murkier than before.
That said, the review overall upholds the impression that steroid abuse is bad for one's mental health and can produce a range of psychiatric manifestations. Reflecting the dearth of information currently available, the article falls short on treatment recommendations beyond general principles of care for drug abusers.
It seems intuitive that the motivations of persons abusing steroids might differ from those of persons who use illicit street drugs.
It's off now Dismiss How do I disable my ad blocker? It can be temporarily disabled by clicking the "shield" icon in the address bar. Close this help box and click "It's off now". Ghostery Click the Ghostery icon on your browser. Skip to main content. Psychiatric Price of Steroid Abuse. Mania , Alcohol Abuse , Bipolar Disorder. Summary Anabolic steroids have gone from an appropriate treatment for men with hypogonadism to an agent abused by athletes, bodybuilders, adolescents, and young adults.
Commentary You hardly need to change television channels to be informed about the latest scandal involving anabolic steroids. How to Recognize and Treat in Primary Care.