HIV and SteroidsResearchers do not yet fully understand all of the interactions that occur anabolic steroids hiv treatment HIV medications and other drugs, and recommendations tend to change over time as new evidence becomes available. However, it is known that the interaction between some HIV medications and recreational drugs hic cause serious complications. Interaction of one drug anabolic steroids hiv treatment another drug can increase its level in the corticosteroids are and even lead to overdose. This kind of risk is greatest when the recreational drug and the HIV medication is processed in the same way by the body, especially in the liver. The risk of drug interaction is greater in the first few weeks or months of taking HIV medication, when the body is adjusting to processing the drugs. Taking a recreational drug at this time could be associated with additional risks.
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Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet]. Anabolic steroids include testosterone and its derivatives. One of the functions of testosterone is to help build muscle. Individuals with HIV infection often lose weight and have low blood levels of testosterone; thus, the use of anabolic steroids in the treatment of weight loss in individuals with HIV infection may be beneficial. The purpose of this review was to evaluate anabolic steroids as a means of treatment of weight loss in individuals with HIV infection.
The review includes 13 randomized clinical trials in the primary analysis. The results suggested that anabolic steroids increased both lean body mass and body weight. However, the results were not consistent among individual trials and the average increase was small and may not be clinically relevant.
Individuals with HIV infection often lose weight during the course of their disease. Furthermore, low serum concentrations of testosterone are common in individuals with HIV infection, particularly those with weight loss. Our objectives were to assess the efficacy and safety of anabolic steroids for the treatment of weight loss in adults with HIV infection.
We searched the following databases: We also searched the bibliographies of the identified studies and review the articles. In addition, pharmaceutical manufacturers of anabolic steroids were contacted. Randomized controlled trials that compared the use of an anabolic steroid to placebo to treat weight loss in adults with HIV were included.
Randomized controlled trials that compared the use of anabolic steroids to placebo for the treatment of weight loss in adults with HIV were selected. Change from baseline in lean body mass or in body weight was reported as on outcome measure.
Data collection and analysis: Two reviewers independently assessed the trials for quality of randomization , blinding, withdrawals, and adequacy of allocation concealment. For continuous data, weighted mean differences WMD were calculated. For dichotomous outcomes, risk differences, were calculated.
Because of uncertainty as to whether consistent true effects exist in such different populations and treatments , the authors decided a priori to use random effects models for all outcomes. Thirteen trials met the inclusion criteria. The mean methodologic quality of the included studies was 4. Although significant heterogeneity was present for both outcomes, the average change in lean body mass was 1. The risk difference for withdrawals or discontinuations of study medication due to adverse events was 0.
Although the results of the trials were heterogeneous , on average, the administration of anabolic steroids appeared to result in a small increase in both lean body mass and body weight as compared with placebo. While these results suggest that anabolic steroids may be useful in the treatment of weight loss in HIV infected individuals, due to limitations, treatment recommendations cannot be made.
In addition, the correlation of improvement in lean body mass with more clinically relevant endpoints, such as physical functioning and survival, needs to be determined. Cochrane Database of Systematic Reviews , Issue 4. Link to Cochrane Library. Number to email 5 10 20 50 Didn't get the message? Number to download 5 10 20 50 Turn recording back on. National Center for Biotechnology Information , U. What is a systematic review? Finding systematic reviews Understanding research results Blog.
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