Anabolic steroids and testicular cancerThis content has not been reviewed within the past year and may not represent WebMD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. April 16, -- Men who use muscle-building supplements containing creatine or androstenedione may have a higher risk of getting testicular canceraccording to a study published online in the British Journal of Anabolic steroids testicular cancer. This risk seems to rise even more among men who begin using the supplements before anabolic steroids testicular cancer 25, who use various kinds of them to build muscle, or who use them for a long time. Statistics of college athletes using steroids people in particular use these products, and the number of users anabolic steroids testicular cancer growing, according to researcher Tongzhang Zheng, who led the study at Yale University. The new study included men diagnosed with testicular cancer between andand men without testicular cancer.
Creatine Linked to Testicular Cancer
Steroids often called anabolic-androgenic steroids AAS or anabolic steroids are becoming more popular among recreational and non-professional power athletes. It is estimated that there are approximately three million steroid users in the USA. As more people look for steroids and start using them, the abuse of steroids and their side effects are becoming major concerns. In this article, we are going to tackle one of the most well known side effects of steroid use: While on steroids, the concentration of androgens in the whole body is high, but the testosterone concentration in the testicles is usually significantly lower due to negative feedback from the brain.
To better understand how this bio-feedback cycle worked, researchers undertook experiments to look at what happened to rat testicles when they were placed on high doses of anabolic steroids. They discovered a reduction in leydig cells which produce testosterone and germs cells precursors to sperm cells and structural changes in the tubules where sperm develop. When testosterone levels in the blood are artificially raised by use of anabolic steroids, the brain sends a signal to the balls to stop producing testosterone.
Steroid users often have difficulty conceiving especially if they experience significant testicular atrophy. Testicles mainly comprise two types of cells—germ cells which make sperm and Leydig cell which secrete testosterone. Because both cell types diminish with androgen use, a common side effect of steroids is low or zero sperm counts and low natural testosterone levels.
These side effects have caused researchers to investigate the possibility of developing an androgen based hormonal contraceptive for men. In the quest to develop a male birth control pill, many studies have been done on using various forms of testosterone in reducing sperm production to values less than 1 million per mL. Due to various side effects and other issues, a hormone based male contraceptive has never been released, but the studies have shown that androgen based drugs including anabolic steroids and testosterone replacement therapy are effective at shutting down sperm production.
In general, once steroid use stops, the testicle begins regenerating lost tissue. Leydig cell counts often remain lower than original, suggesting that testosterone levels may be reduced in the long run. In practice, the longer period you used the steroid for or the higher dose you used , the longer time you will need for your testicles to recover. This is especially true for long term or high dose users. The best way to prevent damage is to not use to begin with. Steroids have a number of other health risks including higher risk of cardiovascular incidents, liver issues and permanent infertility.
However, there are a few tricks that can help prevent testicular atrophy. Using Human chorionic gonadotropin hCG during or in-between cycles is a common practice among steroid users. The hCG, which mimics LH, is often used to avoid the negative feedback on LH and to restart testosterone production by testis. Use of hCG concurrently with TRT or steroid cycle may reduce impact of external androgens on testicular function.
Endocrinologists and many urologists are trained on male hormones and reproduction and can help men identify alternative drugs or therapies to improve recovery of lost tissue, prevent atrophy and maintain fertility. Many of these doctors are very approachable and can be great partners to develop a plan that can help optimize your health to meet goals in the gym and in life.
If it does, why? Steroid causes testicles to shrink. Do shrunken testicles lead to difficulties conceiving? Can testicles go back to normal?
Is there any way to prevent testicular shrinkage for steroid users? Toxicol Lett , 3 , Am J Sports Med , 32 2 , Basic Clin Androl , 26, 2. Physiol Behav , 62 1 , J Reprod Fertil , 2 , BJU Int , 11 , Basic Clin Pharmacol Toxicol , 4 , J Clin Endocrinol Metab , 94 6 , Acta Vet Scand , 38 1 , Passionate about sperm, men's health and helping people build their families.
April 16th, 0 Comments. April 13th, 0 Comments. April 5th, 0 Comments. March 17th, 0 Comments. March 2nd, 0 Comments. Leave A Comment Cancel reply Comment.