Anabolic vs androgenic ratiosI'm allowed a few newbie questions from time to testosterone patch right. Can someone give me a quick definition of what anabolic means Read more or register here to join the discussion below Please complete this form and click anaboliic androgenic anabolic ratio explained below to gain instant access. We hate SPAM and promise to keep androgenic anabolic ratio explained email address safe. Register Help Members Login. Register Gallery Today's Posts Search.
Anabolic steroid - Wikipedia
By henryv , May 29, in Steroid and Testosterone information. In the s when the majority of steroid research was undertaken, before steroids became a dirty word, the goal of the researchers was to develop steroids that could increase muscle mass in cancer patients, burn victims, those with wasting diseases etc. They were trying to develop steroids that were anabolic without being androgenic. Of course medical science has pesky moral objections to testing unknown substances on human test subjects even though these days gymrats are willing to queue round the block to take the latest untested designer steroid compounds , so a system of testing was developed on rats.
The steroids were administered to rats either orally through a gavage tube or by injection. The rats were sacrificed after the experiment which is known as the Hershberger Assay , and the increase in the weights of the levator ani, seminal vesicles, and ventral prostate, were recorded and compared to a standard such as testosterone if by injection or methyl testosterone if administered orally.
The levator ani is the "tail-wagging" muscle in animals, and as such any increase in weight provides a reasonable estimate of the anabolic nature of the compound. The seminal vesicles and the ventral prostate are both involved in the production of semen, and are androgen-sensitive tissues, that is they grow when androgenic compounds are administered.
By using these markers, the scientists tried to make compounds that had a high anabolic value as measured by the levator ani, or L. A and low androgenic value as measured by seminal vesicles, S. In the late s a young scientist called Julius Vida spent a long time collecting and reviewing all the available data on steroids that had been published so far.
The first part of this book was a discussion on the metabolism, and structure and activity relationships of these compounds, while the second part listed steroids, organised by structure, and for each he listed the steroidal nomenclature the chemical name for the drug , a structural diagram of the compound, and the anabolic and androgenic values compared to a standard along with the method of administration used to determine them i.
He also provides a reference number that refers to a bibliography to show which study the figures were originally published in.
Here's an example of one of the compounds listed in Vida's book. I've added some labels to make it a bit more clear.
We aren't concerned about the serial, nomenclature or chemical structure at the present time. Looking at the method of administration, for the top row it is empty meaning that the figures on that row were the result of subcutaneous injection and on the second row it says oral, meaning that the steroid was orally administered to arrive at the figures on that row.
This gives it an anabolic: Methyl test is assumed to be While these figures do not translate literally to their effects on humans, they tend to give a reasonable impression of the nature of a given steroid. In medical science, these would be the first tests they would do on a newly synthesized compound to determine it's initial viability.
If it proved effective, and had a strong dissociation of anabolic and androgenic effects, it may have progressed to further testing and eventually human trials.
Many of the compounds available on the prohormone and designer steroid market today never progressed beyond this initial animal testing stage, and some of them are entirely novel compounds with no scientific testing undertaken at all. Prohormone and Designer Steroid Profiles.
That is the question. Thanks for this Article henryv, very interesting. You'd have to multiply up the numbers by the number of mg's to get an idea of their relative anabolic: I understand what you mean. One of the problems with the A: A figures is that there are large discrepancies between testing conditions from paper to paper, and compounds are often tested at different doses. The point you raise is a valid one.
That doesn't mean it makes you times bigger, it means you have to dose it times lower to achieve comparable results. Anabolic and androgenic ratios were initially useful for scientists deciding which compounds to try out on people for medical purposes.
They aren't a perfect guide to how a compound will affect a bodybuilder though they can give an idea of whether or not the steroid would be a good candidate to resurrect as a designer steroid, and what kind of dosage might be a good idea to try, if no-one's tried that steroid before. The accumulated experiences of the users who have used them are much more useful. You need to be a member in order to leave a comment. Sign up for a new account in our community. Already have an account?
Posted May 29, Anabolic and Androgenic The anabolic: The Hershberger Assay The steroids were administered to rats either orally through a gavage tube or by injection. Viva la Vida In the late s a young scientist called Julius Vida spent a long time collecting and reviewing all the available data on steroids that had been published so far.
These figures form the basis of the anabolic: In Detail Here's an example of one of the compounds listed in Vida's book. In Conclusion While these figures do not translate literally to their effects on humans, they tend to give a reasonable impression of the nature of a given steroid.
By the same author: Share this post Link to post Share on other sites. Posted August 8, Not usre if I'm quite making my self clear there Posted August 10, Thanks for the reply. Good read cheers henry. Create an account or sign in to comment You need to be a member in order to leave a comment Create an account Sign up for a new account in our community.
Register a new account. Sign in Already have an account? Sign In Sign Up.