Growth hormone and testosterone: anabolic effects on muscle.The first step towards the testosterone anabolic effects of understanding anabolic steroids and how they operate is through the thorough understanding of Testosterone itself. Quite literally, all anabolic steroids are synthetic derivatives of Testosteroneor a modification of a derivative of Testosterone. In this case, Testosterone trenes malaga cordoba central what is known as the precursor hormone to the derivative. Other descriptive terms also refer to Testosterone as being the parent hormone, or progenitor testosterone anabolic effects of the derivative or analogue hormone. Testosterone is endogenously manufactured by the human body in the Leydig cells of the testes. There exist two other endogenously manufactured hormones within humans that are testosterone anabolic effects as progenitor hormones to create anabolic steroid derivatives. Nandrolone and Dihydrotestosterone DHT.
Anabolic Steroids: Mechanisms and Effects
Anabolic-androgenic steroids AAS and testosterone are classified as prescription drugs permitted only for the treatment of diseases confirmed by the drug authorities. These diseases include, among others, Testosterone Deficiency Syndrome TDS caused by the pituitary gland or testicles, different kinds of anemia, osteoporosis, and chronic diseases of protein deficiency and prolonged tissue healing.
Testosterone is also used for treatment of male menopause symptoms. Testosterone is administered by syringes containing different kind of testosterone esters for example, testosterone propionate, testosterone enanthate, testosterone phenylpropionate, testosterone isocaproate, testosterone decanoate, testosterone undecanoate or by mouth using testosterone undecanoate capsules.
Anabolic steroids are available both as injections and capsules. The most important reason for using testosterone and anabolic steroids is to increase the muscle mass. On the other hand, by using steroids, people also try to improve their own status in strength sports, for example. Periodic use is characteristic in the abuse of anabolic steroids. The periods of abuse often last from a couple of weeks to several months.
Between them, there are pauses for a couple of months. The dose is increased gradually and the use is discontinued in stages over a week period. Excessive doses are often used [1, 2, 3]. When excessive levels of testosterone and anabolic steroids are introduced to the body, they cause hormonal disturbances.
In men, this suppresses endogenous hormone production. There is structural shrinking in hormone producing glands and organs, such as testicles. The periods of abuse are followed by infertility and weakened sexual functions. In female users, testosterone and anabolic steroids cause excessive growth of body hair, lowering of the voice, reduction in breast size, balding, enlargement of the clitoris, skin problems and menstrual cycle disturbances.
Some of these changes may be permanent. When used in excessive doses, both testosterone and anabolic steroids cause harmful changes in cholesterol levels.
Thus the continuous use of these hormones will increase the risk of developing heart and vascular diseases, heart infarct and apoplexy. Steroids weaken the cardiac contractile force and cause cardiac muscle degeneration, which can lead to cardiac arrhythmia and sudden death [6, 7, 8]. Abuse of AAS and testosterone increases the risk of diabetes. The sharing of syringes with other users increases the possibility of getting blood-transmitted diseases such as hepatitis and HIV.
Excessive use of testosterone and anabolic steroids also increases the risk of cancer and liver damage [1, 9]. Anabolic steroids that are administered orally are more harmful to the liver than injected anabolic steroids.
Liver diseases vary from reversible, slight cell damage and yellowness to malignant liver tumors with a bad prognosis even when treated. Testosterone and anabolic steroids also affect the central nervous system.
The locations in the brain where they have effects are closely connected to the centers that adjust mood, sexuality and aggressiveness . About 20 to 30 percent of the people who use excessive doses of testosterone and anabolic steroids have obvious mood disorders that meet the criteria of psychiatric disease classification, such as depression, anxiety, psychotic reactions with hallucinations, and decrease in cognitive performance levels [2, 4, 6].
About 30 percent of the people who use excessive doses of testosterone and anabolic steroids are aggressive, hostile and irritated during the intake period. Based on several case reports, hormones weaken impulse control . These include reports of previously stable individuals becoming violent following hormone consumption. According to a Finnish population-based study , the risk of anabolic steroid and testosterone abusers dying prematurely was 4.
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Southern Medical Journal Concomitant abuse of anabolic androgenic steroids and human chorion gonadotropin impairs spermatogenesis in power athletes. International Journal of Sports Medicine Long-term psychiatric and medical consequences of anabolic—androgenic steroid abuse: A looming public health concern?
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Forensic Science International Steroid use and long-term health risks in former athletes. Sports Medicine 32 2: Medical Science Monitor 11 4: Increased premature mortality of competitive powerlifters suspected to have used anabolic agents.
Skip to main content. Anabolic steroids and testosterone. Medical use Anabolic-androgenic steroids AAS and testosterone are classified as prescription drugs permitted only for the treatment of diseases confirmed by the drug authorities.
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