Glyceryl UndecylenateProduction proceeds from fully refined vegetable oils, which are further processed using hydrogenation and fractionation techniques, and the end products are produced by reacting selected mixtures of the partly hydrogenated, partly fractionated oils and fats with vegetable-derived glycerine to is glyceryl undecylenate safe partial glycerides. In the final stage of the production process, the products are purified by deodorization, which effectively removes jndecylenate residues and lower boiling residues such as residues of halogenated solvents and glycetyl solvents. Nominally, steroidi prodaja novi sad ingredients are 1,3-diglycerides, but are easily isomerized to the 1,2-diglycerides form. The 1,3-diglyceride isomer is not a significant toxicant in acute, short-term, subchronic, or chronic animal tests. Glyceryl Dilaurate was a mild primary irritant in albino rabbits, but not a skin sensitizer in guinea pig maximization tests. Diacylglycerol Is glyceryl undecylenate safe was not genotoxic in the Ames test, in mammalian Chinese hamster lung cells, or in a rodent undecyleenate marrow micronucleus assay.
Glyceryl Undecylenate | Cosmetics Info
Production proceeds from fully refined vegetable oils, which are further processed using hydrogenation and fractionation techniques, and the end products are produced by reacting selected mixtures of the partly hydrogenated, partly fractionated oils and fats with vegetable-derived glycerine to yield partial glycerides. In the final stage of the production process, the products are purified by deodorization, which effectively removes pesticide residues and lower boiling residues such as residues of halogenated solvents and aromatic solvents.
Nominally, these ingredients are 1,3-diglycerides, but are easily isomerized to the 1,2-diglycerides form. The 1,3-diglyceride isomer is not a significant toxicant in acute, short-term, subchronic, or chronic animal tests. Glyceryl Dilaurate was a mild primary irritant in albino rabbits, but not a skin sensitizer in guinea pig maximization tests. Diacylglycerol Oil was not genotoxic in the Ames test, in mammalian Chinese hamster lung cells, or in a rodent bone marrow micronucleus assay.
An eye shadow containing 1. A trade mixture containing an unspecified concentration of Glyceryl Dibehenate did not induce irritation or significant cutaneous intolerance in a h occlusive patch test. In maximization tests, neither an eye shadow nor a foundation containing 1.
Phototoxicity or photoallergenicity was not induced in healthy volunteers tested with a lipstick containing 1. In the absence of initiation, Glyceryl Distearate induced a moderate hyperplastic response in randomly bred mice of a tumor-resistant strain, and with 9,dimethyl-1,2- benzanthracene DMBA initiation, an increase in the total cell count was observed.
In studies of the tumor-promoting activity of 1,2-diacylglycerols, dose and the exposure regimen by which the dose is delivered play a role in tumor promotion. The 1,2-diacylglycerol-induced activation ofPKCmay also relate to the saturation of the fatty acid in the 1 or 2 position; 1,2-Diacylglycerols with two saturated fatty acids are less effective.
Also, the activity of 1,2-diacylglycerols may be reduced when the fatty acid moiety in the structure is a long-chain fatty acid. A histological evaluation was performed on human skin from female volunteers 18 to 56 years old who had applied a prototype lotion or placebo formulation, both containing 0. Skin irritation was not observed in any of the subjects tested. Biopsies 2mm taken fromboth legs of five subjects indicated no recognizable abnormalities of the skin; the epidermis was normal in thickness, and there was no evidence of scaling, inflammation, or neoplasms in any of the tissues that were evaluated.
The Cosmetic Ingredient Review CIR Expert Panel considered that the available safety test data indicate that diglycerides in the 1,3-diester form do not present any significant acute toxicity risk, nor are these ingredients irritating, sensitizing, or photosensitizing.
Whereas no data are available regarding reproductive or developmental toxicity, there is no reason to suspect any such toxicity because the dermal absorption of these chemicals is negligible. The Panel noted that these nominally 1,3-diglycerides contain 1,2- diglycerides, raising the concern that 1,2-diglycerides could potentially induce hyperplasia.
Data regarding the induction ofPKCand the tumor promotion potential of 1,2-diacylglycerols increased the level of concern. The Panel considered it particularly important that a week use study of a prototype lotion containing 0.
The Panel understands that use testing is a common practice in industry and, if histopathology data are collected, the Panel believes that such an approach can demonstrate an absence of epidermal hyperplasia. In the absence of inhalation toxicity data on the Glyceryl Diesters in this safety assessment, the Panel determined that these ingredients can be used safely in aerosolized products because they are not respirable.
The Panel recognizes that certain ingredients in this group are reportedly used in a given product category, but the concentration of use is not available. For other ingredients in this group, information regarding use concentration for specific product categories is provided, but the number of such products is not known.
In still other cases, an ingredient is not in current use, but may be used in the future. Although there are gaps in knowledge about product use, the overall information available on the types of products in which these ingredients are used and at what concentration indicate a pattern of use. Within this overall pattern of use, the CIR Expert Panel considers all ingredients in this group to be safe.
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click on download. Skip to main content. International Journal of Toxicology.
Download PDF Article information. Permissions Request Permissions View permissions information for this article. Send me a copy Cancel. Diacylglycerol-induced melanogenesis in Skh-2 pigmented hairless mice.
Topically applied diacylglycerols increase pigmentation in guinea pig skin. Enhancement of naloxone penetration through human skin in vitro using fatty acids, fatty alcohols, surfactants, sulfoxides and amides. Unpublished data submitted by CTFA. Unpublished data submitted by 2 Google Scholar.
Regulation of protein kinase C and role in cancer biology. Protein kinase C in signal transduction and carcinogenesis. Google Scholar , Medline. Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of proetin kinase Cdelta: Possible correlation with tumor-promoting activity. Beta2-chimaerin is a novel target for diacylglycerol: Antimicrobial action of esters of polyhydric alcohols.
Concentration of use data and specifications from Japanese references. Use concentration data on gyceryl diesters from industry survey. Reportonthe effectofglyceryl diesters on DNA synthesis in normal human dermal fibroblasts. A modified Draize repeat insult patch test in healthy volunteers to investigate the irritation and sensitization potential of nine cosmetic ingredients of edible quality and a control liquid paraffin following repeated cutaneous patch applications Report No.
Unpublished data submitted by Danisco Ingredients, February, Impurity analysis for glycerol monoesters. Acyl migration solid phase isomerization of 1,2-diglycerides to 1,3-isomers. Final report on the safety assessment of Isostearic Acid. Final report on the safety assessment of Arachidonic Acid. Information about 1,2-diester levels in glyceryl diesters. Federation of American Societies for Experimental Biology.
Evaluation of the health aspects of glycerin and glycerides as food ingredients. Oral toxicities of lauric acid and certain lauric acid derivatives. C log P values calculated for glyceryl dilaurate and glyceryl distearate.
Personal communication with Dr. Frequency of use of cosmetic ingredients. Analysis of mono-, di-and triglycerides in pharmaceutical excipients by capillary super critical fluid chromatography. Further studies on the specificity of diacylglycerol for protein kinase C activation. Differential down-regulation of epidermal protein kinase C by O-tetradecanoylphorbolacetate and diacylglycerol: Association with epidermal hyperplasia and tumor promotion.
Lipstick dermatitis due to C18 aliphatic compounds. Verification of the good epicutaneous local tolerance of a cosmetic test article, after a single application to the skin of the back and under occlusive patch for 48 hours, in 10 healthy adult volunteers: Institut Francais de Recherches et Essais Biologiques. Comments on the composition of glyceryl mono-, di-, and triesters, by Karl Enters and Mark Rerek. Inveresk Research International Limited.
Vegetable fats for cosmetic use: A human repeat insult patch test Report No. Analytical testing to determine the percentage of 1,2 diester fraction 1,2-dilauryl-s, n-glycerol in Emulsynt GDL, glycerol laurate, material on an as sold basis. Karl Enters to Gerald McEwen. The determination of the contact-sensitizing potential of one material by means of the maximization assay Final Report. An evaluation of the contact-sensitization potential of a topical coded product in human skin by means of the maximization assay Final Report.
Principles techniques and applications, ed. John Wiley and Sons. The influence of particle size. Spray Technology and Marketing. Natural and synthetic fatty acids and monoglycerides. Genotoxicity studies on dietary diacylglycerol DAG oil. Stoichiometric binding of diacylglycerol to the phorbol ester receptor. Differential interaction of delta-lactones and gamma-lactones with protein kinase C PK-C. Google Scholar , Crossref , Medline.
Signal transduction in vascular smooth muscle: Diacylglycerol second messengers and PKC action. Conformationally constrained analogues of diacylglycerol. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template. Ultrapotent protein kinase C ligands based on a a chiral 5-disubstituted tetrahydro2-furanone template. Effect of in vivo treatment with quinagolide. CRC handbook of chemistry and physics.
A ready-reference book of chemical and physical data, , — , — The digestion and absorption of triglycerides. MB Research Laboratories, Inc. Single dose oral toxicity in rats Project No.