Testosterone depot injection in male hypogonadism: a critical appraisalTestosterone compounds have been available for almost 70 years, but the pharmaceutical formulations have been testosterone patch than ideal. Traditionally, injectable testosterone esters have been used for treatment, but they generate supranormal testosterone levels shortly after the testosterone decanoate injections to 3-weekly injection interval and then order dianabol levels decline very rapidly, becoming subnormal in the injectiins before the next injection. The rapid testosterone decanoate injections in plasma testosterone are subjectively experienced as disagreeable. Testosterone undecanoate is a new testosterone decanoate injections testosterone preparation with a considerably better pharmacokinetic profile. After 2 initial injections with a 6-week interval, the following intervals between two injections are almost always weeks, amounting eventually to a ddecanoate of 4 injections per year. Plasma testosterone levels with steroid abuse treatment centers preparation are nearly always in the range of normal men, so are its metabolic injecitons estradiol and dihydrotestosterone.
Testosterone depot injection in male hypogonadism: a critical appraisal
J Sex Med ;7 6: The primary efficacy endpoints were the changes in International Index of Erectile Function IIEF score from the initial visit to the final visit 24 weeks and from the initial visit to each visit.
A variety of delivery methods of testosterone therapy have been developed, including oral preparations, transdermal gels, buccal systems, skin patches, subcutaneous implants and intramuscular injections. The formulation of mg of testosterone undecanoate in an oily vehicle castor oil provides a safe and well-tolerated long-acting intramuscular injection which has been shown to sustain stable physiological levels of testosterone with extended intervals of administration every 10—14 weeks in studies in Europe.
However, efficacy and safety data of this long-acting testosterone undecanoate injection in Asian populations have been lacking. This study showed that the testosterone undecanoate injection is effective, safe and well tolerated in Korean men with testosterone deficiency. As all patients in the study reported ED at the start of the study, it was expected that the sexual subscale score of the AMS would be improved more than other subscales.
However, there was significant improvement in all subscale scores within 6 weeks of starting therapy, which was maintained throughout the study. Similarly, the IIEF data showed that there were significant improvements in sexual desire, intercourse satisfaction and overall satisfaction, in addition to erectile function and orgasmic function. A longer follow-up period may have been necessary to further assess the effect of testosterone therapy on lipid profile and metabolic components in Asian men.
Treatment of male hypogonadism with testosterone undecanoate injected at extended intervals of 12 weeks: J Androl ;23 3: J Clin Endocrinol Metab ;89 How to diagnose hypogonadism? Testosterone Tools Check out the testosterone tools for conversion, management and effectiveness of treatment. Information for healthcare professionals. No serious adverse reactions were observed. What this study adds This study showed that the testosterone undecanoate injection is effective, safe and well tolerated in Korean men with testosterone deficiency.
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