Juvenile Idiopathic Arthritis Treatment & ManagementDiagnosis of juvenile idiopathic arthritis can be difficult because joint pain can be caused by many jra steroid treatment types of problems. No single test can confirm a diagnosis, but tests sterile injectables testosterone help rule out some other conditions that produce similar signs and symptoms. In many children with juvenile idiopathic arthritis, no significant abnormality will be found in these blood tests. X-rays or magnetic resonance imaging MRI may be taken to exclude other conditions, such as fractures, tumors, infection or congenital defects. Imaging may also be jra steroid treatment from time to time after the diagnosis to monitor bone development and to detect joint damage. Treatment for juvenile idiopathic arthritis focuses on helping your child maintain a normal level of physical and social activity. To accomplish this, doctors may use a steroix of strategies to relieve pain and swelling, jra steroid treatment full movement and strength, and prevent complications.
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Juvenile idiopathic arthritis JIA is the umbrella term under which several forms of chronic arthritis in children are categorized. One or more joints must demonstrate evidence of inflammation characterized by swollen joints , limitation in the range of motion of the involved joint s , tenderness when the joint is moved, and increased warmth of the joint region. These symptoms must be present even intermittently for at least six weeks and affect a child less than 16 years of age. JIA is the most frequent chronic rheumatologic disease of childhood, and the cause s are not well understood.
Both environmental and genetic influences are felt to contribute to the development of signs and symptoms of JIA. Knowledgeable specialists pediatric rheumatologists usually affiliated with pediatric teaching hospitals can help to limit the possibility of complications of juvenile idiopathic arthritis including leg-length discrepancy, joint contractures, and destruction and blindness due to inflammation of the eye iritis.
Until the late s, JIA was known in the U. The revised name was devised in order to better distinguish the childhood disease from rheumatoid arthritis RA that affects adults. This new nomenclature has enabled the categorization of six JIA subtypes. This updated classification has helped to foster better communication among those doing research on causation, clinical manifestations, and therapy of JIA.
JIA is considered a diagnosis of exclusion; the diagnosis can only be confidently made when 1 the patient's history, physical exam, and laboratory findings are consistent with those described in the literature by the International League of Associations for Rheumatology and 2 other conditions have been excluded. While early RA symptoms can be mimicked by other diseases, the symptoms and signs are very characteristic of rheumatoid disease. The 15 early rheumatoid arthritis symptoms and signs discussed in this article include the following:.
The specific criteria necessary to establish a diagnosis and prognosis for each category are detailed below. While no specific cause s of JIA have been determined, there is strong evidence of both genetic and environmental factors being implicated in the development of the disease.
Studies of nonidentical siblings show evidence that if one child develops JIA there is a 15 to 30 times increased risk that a sibling will develop the condition when compared to the general pediatric population.
The biologic and clinical manifestations of JIA provide strong evidence that a general theme of an immune system misdirection is evident. The immune system has two "arms" -- the cell based lymphocytes, etc. Rheumatologists have demonstrated that both of these elements of the immune system react against the patient's own body structures joints, muscles, eye tissues, etc. Much research is currently focused in an effort to better understand this auto-inflammatory process in the hope that understanding the cause of JIA will enable better and more effective treatments and ultimately a cure for the condition.
The International League of Associations of Rheumatology has classified JIA into six distinct patterns that vary by clinical presentation and evolution of symptoms, laboratory implications, potential complications, and therapeutic options. While some similarities exist among these diseases, the uniqueness of each manifestation of JIA is strong enough to justify the breakdown into the six patterns.
One characteristic common to all six forms of JIA is that of "morning stiffness" that improves during the day as more movement is done. Likewise, spontaneous patterns of worsening and lessening of symptoms which may be independent of therapy is characteristic. By definition, systemic onset JIA must have arthritis swelling, pain, and warmth of one or more joints associated with a minimum of two weeks of daily spiking fevers.
The fever is often greater than F 39 C and usually spikes once or twice a day and may have the unique pattern of returning to below normal between rises. During febrile episodes, children appear moderately sick, but with resolution of fever they are much improved. There is no gender preference the frequency in boys and girls is equal , with symptoms generally starting between years of age. There is no unique laboratory test for JIA, but children typically have anemia and elevation of white blood cell and platelet counts, as well as alterations of general markers of inflammation.
Complications of systemic onset JIA may include slower than expected growth, weakening of bones, abnormalities of liver and lung function, and consequences of therapy see below. Since the diagnosis of systemic onset of JIA is one of exclusion, the possibility of infection, malignancy, collagen vascular disease , and rheumatic fever must also be considered.
Oligoarticular is defined as arthritis that affects four or fewer joints in the first six months of the disease. One group consists of those children who continue throughout the entire course of their disease having four or fewer joints involved. The other group eventually develops greater than four-joint involvement after the first six months of illness. The onset of disease is between years of age with a female gender bias of approximately 3: Symptoms of joint pain and tenderness are worse in the morning in association with the previously described morning stiffness see systemic onset JIA.
The primary complication of oligoarticular JIA is inflammation of the iris the colored region of the eye. Complications of iritis may include clouding of the cornea cataracts , glaucoma , and vision loss. Since outcome is linked to early diagnosis, it is imperative an ophthalmologist evaluate children with oligoarticular JIA every three to four months. Conditions that should be eliminated prior to establishing a diagnosis of oligoarticular JIA include trauma, infection, malignancy, and arthritis following an infection.
Polyarticular juvenile idiopathic arthritis: Children who have five or more joints involved with arthritis during the first six months of their disease are classified into the polyarticular JIA form of illness. Two subgroups of polyarticular JIA exist based upon a constellation of various laboratory studies. Late childhood through young teenage girls are the most likely to develop this pattern.
Generally, small joints such as the hands and feet tend to be involved, and a more aggressive course has been observed. Fatigue , anemia , suboptimal growth, and iritis to a lesser degree than oligoarticular JIA are complications.
Other conditions that must be considered and eliminated prior to establishing the diagnosis of polyarticular JIA include infection, malignancy, and collagen vascular disease including systemic lupus erythematosus.
Establishing the diagnosis of psoriatic arthritis involves demonstration of both large and small joint arthritis and a characteristic rash psoriasis. Should the rash not be present, two of the following must exist: Children with psoriatic arthritis may also develop iritis and should have ophthalmologic evaluation every six months.
Enthesitis inflammation at the site of tendon insertion on the bone most profoundly affects males over 8 years of age and often involves the lower back, sacroiliac joints, and joints of the legs, ankles, and feet. The male to female ratio is 7: Providing an accurate prognosis and developing a treatment program are challenges. While there currently is no cure for JIA, an integrated and coordinated approach has been shown to be helpful in lessening the morbidity nonlethal side effects of JIA.
Goals include lessening pain, joint contractures, and growth disturbances see above. Monitoring for the development of iritis and aggressive treatment are also paramount. Often patients are best served at a pediatric teaching hospital where access to pediatric rheumatologists, physical and occupational therapists, pharmacologists, and social support providers may allow "one stop shopping.
Nonsteroidal anti-inflammatory drugs NSAIDs are commonly used as the first line of therapy due to their positive effect of reducing inflammation in arthritis and relatively few side effects. Medications such as ibuprofen Advil , Motrin , naproxen Aleve , and indomethacin Indocin are examples of this class of therapy. Steroids are another common class of medications for those experiencing moderate to severe arthritis or nonarthritis inflammatory consequences of JIA.
These medications may be administered orally prednisone [ Deltasone ], prednisolone [ Pediapred ] , intravenously methylprednisolone [ Solu-Medrol ], dexamethasone [Decadron], hydrocortisone [ Solu-Cortef ] , or injected directly into an involved joint methylprednisolone [ Depo-Medrol ], triamcinolone [Kenalog].
Side effects of steroids may be considerable, and pediatric rheumatologists strive to use the lowest possible dosage. Antirheumatic medications also known as disease-modifying antirheumatic drugs or DMARDs are needed in approximately two-thirds of children to control the joint changes and prevent damage of JIA. These medications are generally considered when the medications previously described are not providing effective control of the illness.
Medicines in this category include methotrexate Trexall , now considered the "gold standard" for JIA, sulfasalazine Azulfidine , azathioprine Imuran , cyclosporine Sandimmune , Neoral , and others. These medications are administered orally or intravenously. Antirheumatic medications are more potent in effect but also can have significant side effects.
All of these medications require regular blood testing to monitor for side effects. Problems include immune suppression, which may cause an increased risk of infection, certain cancers , bone marrow toxicity, pulmonary toxicity, liver function abnormalities, abdominal pain , and decrease in appetite.
Biologic agents can lessen the morbidity for children with JIA. These agents are administered either by superficial injection under the skin or intravenously. Their general chemical classification is that of "monoclonal antibodies" that work by accurately targeting various mechanisms of the immune system that are overactive and misdirected in JIA.
They are associated with an increased risk of infections and rarely development of certain malignancies. As such, close clinical monitoring and various laboratory studies are required. Examples of biologics used in the treatment of JIA include etanercept Enbrel , anakinra Kineret , adalimumab Humira , tocilizumab Actemra , and abatacept Orencia. Autologous stem cell transplantation is reserved only for those children with JIA who have failed the above therapeutic options.
This procedure requires hospitalization and is a two-step process. The initial goal is utilization of high-dose immune suppression medications to remove the patient's lymphocytes a type of white blood cell that are attacking the patient's joint s.
Once removed, new stem cells from the patient autologous that were previously harvested and treated are introduced back into the patient's body via the bloodstream. This process requires expertise found only in a few pediatric referral centers. Perhaps the most insidious and most devastating complication of JIA is a form of eye inflammation of the iris of the eye called iritis.
The risk for iritis is variable depending upon the subtype of JIA. The highest risk group is oligoarticular JIA while patients with systemic onset JIA are at a low risk of this complication. It is imperative that all JIA patients have thorough ophthalmologic examinations in order to detect any changes that would herald the onset of iritis. Another common complication of JIA is growth disturbances such as a difference in leg lengths.
Interestingly, the involved joint such as the knee has an increase in blood flow due to the inflammatory nature of the local arthritis. This increase in blood flow encourages the area of bone growth growth plate to maximum activity and thus the involved leg is longer than the non-involved limb.
However, as the disease progresses, the chronic nature of arthritis can damage the growth plate region causing premature fusion and thus the involved leg will be retarded relative to the uninvolved limb.
Many patients experience moderate pain of the joints involved resulting in limited use of the region. As a result, loss of calcium from the bone can result in osteoporosis.
These children and their parents may also fall victim to emotional stress associated with any chronic illness. Long-term low-grade pain may stimulate a sense of helplessness and hopelessness and thus depression. Children often have a limited social life especially with their peers due to school absenteeism. It must also be remembered that the medical therapies commonly used to treat JIA can have many have prominent side effects see above.
In patients who have active disease into adulthood, there can be significant disability with functional limitations. Outcome may reflect duration of disease, presence of polyarticular involvement, and the need for systemic steroids. What is rheumatoid arthritis? What causes rheumatoid arthritis? Is rheumatoid arthritis hereditary?