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Growth hormone GH is a naturally occurring hormone secreted by the pituitary gland. Levels of GH naturally decline with age. In some people, however, a deficiency of GH causes several health problems, such as impaired growth. Replacement GH was originally obtained from cadavers for medical use; however, this source was contaminated with substances that caused Creutzfeldt-Jakob disease. Whereas GH is approved for the previously listed disorders, there is growing interest in using GH therapy as a means to treat chronic fatigue syndrome, fibromyalgia, battered- wife syndrome, and obesity.
This therapy also has picked up interest as an athletic performance enhancer and as an antiaging treatment, 1 and it is heavily marketed in the OTC realm for both of these uses. Further studies need to be done to determine the efficacy and risks; however, GH-related products are still being used extensively in the OTC market, and these products will be discussed in this article.
The decline in GH associated with age contributes to increased visceral adipose tissue, decreased lean body mass, decreased bone mass, reduced exercise capacity, and thinning of the skin.
The purpose of using GH-related products as athletic performance enhancers is to achieve the same results? To actually sell growth hormone without a prescription or as a dietary supplement is illegal.
Section F of the US Federal Food, Drug, and Cosmetic Act prohibits the distribution or possession with the intention of distributing human growth hormone without a medical condition that requires treatment. If someone does distribute or possess it illegally, he or she may face imprisonment and a fine. There are many homeopathic products available, however, that claim to provide a diluted form of growth hormone.
This document states that "a homeopathic drug is any drug labeled as homeopathic which is listed in the Homeopathic Pharmacopeia of the United States HPUS , an addendum to it, or its supplements. There also are HGH creams that penetrate the skin and go directly into the bloodstream.
These creams are mainly used as antiaging products. Product manufacturers claim that this homeopathic form of GH will stimulate the pituitary gland to release more GH and that it is virtually free of side effects. These products are often called GH secretagogues; they come in pill or powder form. They contain no GH, but, instead, amino acids that manufacturers claim cause the body to increase the production of GH. Common amino acids in these products are glutamine, arginine, ornithine, phenylalanine, and lysine.
These substances are used in many sports supplements. Enhancer product manufacturers claim that they are virtually free of side effects and safe; however, limited studies have been done to prove their efficacy and safety. There is also an enhancer available in a liquid form that is sprayed under the tongue, in the mouth, or in the nose.
Again, no studies have been done to prove that this therapy is safe and effective. Of note, many other OTC products claim to contain GH-related products but do not contain any hormone or ingredient to promote growth at all.
Growth hormone use is not without potential risks and side effects. The prescription GH products are associated with swelling of the hands and feet and musculoskeletal pain that is usually self-limiting or can be treated with analgesics.
Other conditions that have been associated with the prescription products are gynecomastia, intracranial hypertension, and development of antibodies to the growth hormone protein.
Side effects, although rare, have been seen with use of the OTC products as well. They include elongation of the forehead, hands, and feet; overgrowth of the elbows or jaw; thickening of the skin; and insulin resistance.
The patient has a right to know the risks of using these products and that the possible benefits may not outweigh the risks. Many companies use the prescription product the injectable form of GH data and apply it to the homeopathic OTC products.
The FDA requires that information presented must be based on the exact product being sold. Pharmacists should be careful when looking at "supporting data. For a list of references, send a stamped, self-addressed envelope to: Sign up for the PharmacyTimes Newsletter. Clinical Resources Acute Coronary Syndrome. Potential Risks Growth hormone use is not without potential risks and side effects.
What to Believe Many companies use the prescription product the injectable form of GH data and apply it to the homeopathic OTC products. Amazon Withdrawals Plans for Medication Distribution.
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