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the can treated by Some are: CBD conditions be of that

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27.06.2018

Content:

  • the can treated by Some are: CBD conditions be of that
  • 8 Medical Conditions That CBD Can Help Treat
  • Explore Everyday Health
  • Any relevant reports that have been included in the areas below have been culled from PubMed, an online service of the U.S. National Library of Medicine. Cannabis sativa L. preparations have been used in medicine for millenia. Numerous diseases, such as anorexia, emesis, pain, inflammation, multiple . There are some negative effects of cannabis use other than addiction, most of . can also be treated with cannabis extracts containing THC, or CBD, or with Sativex. Jan 3, 8 Medical Conditions That CBD Can Help Treat in recent years concerning CBD's medical usefulness, including some diseases and ailments.

    the can treated by Some are: CBD conditions be of that

    Since then cannabinoids were found to act on various cancer cell lines, through various mechanisms. Moreover, cannabinoid challenge decreased the efficiency of glioma stem-like cells to initiate glioma formation in vivo.

    Activation of these receptors decreased growth, proliferation, angiogenesis, and metastasis, and increased apoptosis, of melanomas in mice. These effects were prevented by blockade of the CB2 cannabinoid receptor or by pharmacologic inhibition of ceramide synthesis de novo. THC inhibited tumor-cell proliferation in vitro, decreased tumor-cell Ki67 immunostaining and prolonged the survival time of two of the patients.

    Many drugs used today can cause addiction and are misused and abused, for example opiates, cocaine, benzodiazepines, barbiturates, cholinergic agonists, ketamine, , dopaminergic agonists, amphetamines, and others. Nevertheless they are still an important part of our pharmacopeia.

    Marijuana was used for centuries as a medicinal plant, but during the last century, because of its abuse and addictive potential it was taken out of clinical practice. Now, we believe that its constituents and related compounds should be brought back to clinical use.

    The endocannabinoid system is a very complex one and regulates numerous processes, in parallel with other wellknown systems, such as the adrenergic, cholinergic, and dopaminergic systems. National Center for Biotechnology Information , U. Journal List Dialogues Clin Neurosci v. Kogan , MSc Natalya M. Author information Copyright and License information Disclaimer. This is an open-access article distributed under the terms of the Creative Commons Attribution License http: This article has been cited by other articles in PMC.

    Abstract Cannabis sativa L. Abstract Las preparaciones de Cannabis sativa L. Addiction to canabis, and the influence of cannabis on addiction to other substances Marijuana may produce mild dependence in humans. Negative effects of cannabis other than addiction There are some negative effects of cannabis use other than addiction, most of them related to alterations of attentional and cognitive functions or other neuropsychological and behavioral effects.

    Therapeutic uses of cannabinoids Obesity, anorexia, emesis Cannabis has been known for centuries to increase appetite and food consumption. Pain Cannabis has been used for millennia as a pain-relieving substance. Multiple sclerosis, neuroprotection, inflammation Inflammation, autoimmune response, demyelination, and axonal damage are thought to participate in the pathogenesis of MS.

    Parkinson's disease, Huntington's disease, Tourette's syndrome, Alzheimer's disease, epilepsy Parkinson's disease PD is a chronic, progressive neurodegenerative disorder. Bipolar disorder, schizophrenia, post-traumatic stress disorder PTSD , depression, anxiety, insomnia Cannabis use is common in patients with bipolar disorder, and anecdotal reports suggest that some patients use marijuana to alleviate symptoms of both mania and depression.

    Asthma, cardiovascular disorders, glaucoma Asthma is a chronic disease of the respiratory system in which the airway occasionally constricts, becomes inflamed, and is lined with excessive amounts of mucus. Cancer The antiproliferative action of cannabinoids on cancer cells was first noticed in the s.

    Conclusion Many drugs used today can cause addiction and are misused and abused, for example opiates, cocaine, benzodiazepines, barbiturates, cholinergic agonists, ketamine, , dopaminergic agonists, amphetamines, and others. Early medical use of cannabis.

    Untersuchung der Cannabis sativa. Repertorium fur die Pharmacie. Note sur le haschisch. A historical overview of chemical research on cannabinoids. Isolation, structure and partial synthesis of the active constituent of hashish. J Am Chem Soc. Marihuana, an annotated bibliography. Withdrawal symptoms in cannabis indica addicts. The addictive potential of cannabis. Clinical studies of cannabis tolerance and dependence.

    Ann N Y Acad Sci. Treatment of cannabis use disorders: Cannabis addiction and Telic Dominance Scale. Clinical trial of abstinencebased vouchers and cognitive-behavioral therapy for cannabis dependence. J Consult Clin Psychol. Addictive potential of cannabinoids: Failure of Delta 9 -tetrahydrocannabinol and CP 55, to maintain intravenous self-administration under a fixed-interval schedule in rhesus monkeys.

    Endocannabinoid system and alcohol addiction: Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. SR, a central cannabinoid CB 1 receptor antagonist, blocks the motivational and dopaminereleasing effects of nicotine in rats.

    The diagnosis of alcohol and cannabis dependence addiction in cocaine dependence addiction. Behavioral effects of cocaine alone and in combination with ethanol or marijuana in humans. Marihuana smoking increases plasma cocaine levels and subjective reports of euphoria in male volunteers. Involvement of cannabinoid CB1 receptors in drug addiction: Rimonabant, a CB1 antagonist, blocks nicotineconditioned place preferences. Nicotine-associated cues maintain nicotine-seeking behavior in rats several weeks after nicotine withdrawal: The role of the cannabinoid system in nicotine addiction.

    Successful control of lipids, kilos and cigarettes]. Advances in pharmacotherapy for tobacco dependence. Expert Opin Emerg Drugs. Expert Opin Investig Drugs. Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats.

    Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: Cell Mol Life Sci. Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J Pharmacol Exp Ther. Cognitive functioning of longterm heavy cannabis users seeking treatment. Chronic cognitive impairment in users of 'ecstasy' and cannabis.

    Cannabis use, cognitive performance and mood in a sample of workers. Long-term effects of frequent cannabis use on working memory and attention: Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring.

    A literature review of the consequences of prenatal marihuana exposure. An emerging theme of a deficiency in aspects of executive function. Cannabis, the mind and society: Cannabis and cognitive dysfunction: The psychotomimetic effects of intravenous deItatetrahydrocannabinol in healthy individuals: Amotivational syndrome in organic solvent abusers. Characteristics of abnormal behavior induced by delta 9-tetrahydrocannabinol in rats.

    Psychiatric aspects of cannabis use in adolescents and young adults. Related, induced and associated psychiatric disorders to cannabis. Operant acquisition of marihuana in man. Cannabis, motivation, and life satisfaction in an internet sample.

    Subst Abuse Treat Prev Policy. Endocannabinoids in the regulation of appetite and body weight. Endocannabinoids in appetite control and the treatment of obesity. Genetic variations at the endocannabinoid type 1 receptor gene CNR1 are associated with obesity phenotypes in men. J Clin Endocrinol Metab. Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats.

    The role of CB1 receptors in sweet versus fat reinforcement: SR , a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset. Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: Fighting obesity and associated risk factors by antagonising cannabinoid type 1 receptors. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: Clinical trials update and cumulative meta-analyses from the American College of Cardiology: Eur J Heart Fail.

    Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: Rimonabant in obese patients with type 2 diabetes. Am J Health Syst Pharm. Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia.

    J Pain Symptom Manage. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. Dronabinol effects on weight in patients with HIV infection. The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. Cannabinoids in the treatment of the cachexiaanorexia syndrome in palliative care patients.

    A phase II study of deltatetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. Mechanism of action of cannabinoids: An efficient new cannabinoid antiemetic in pediatric oncology. Cannabinoids for control of chemotherapy induced nausea and vomiting: Therapeutic potential of cannabinoids in trigeminal neuralgia. Cannabinoids block release of serotonin from platelets induced by plasma from migraine patients. Int J Clin Pharmacol Res. Are oral cannabinoids safe and effective in refractory neuropathic pain?

    Lack of analgesic efficacy of oral deItatetrahydrocannabinol in postoperative pain. Pain relief with oral cannabinoids in familial Mediterranean fever.

    Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial. Effect of the synthetic cannabinoid dronabinol on central pain in patients with multiple sclerosis - secondary publication. The analgesic properties of deItatetrahydrocannabinol and codeine.

    Analgesic effect of deItatetrahydrocannabinol. Cannabis use for chronic non-cancer pain: Cannabis use in HIV for pain and other medical symptoms. Experience with the synthetic cannabinoid nabilone in chronic noncancer pain. Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain: Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: Cannabimimetic properties of ajulemic acid.

    A tale of two cannabinoids: Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain. Curr Med Res Opin. Initial experiences with medicinal extracts of cannabis for chronic pain: Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.

    Combined cannabinoid therapy via an oromucosal spray. Cannabinoids for the treatment of pain: An update on recent clinical trials. Dexanabinol HU effect on experimental autoimmune encephalomyelitis: Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.

    Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis. Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice. Marihuana as a therapeutic agent for muscle spasm or spasticity. Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. DeltaTHC in the treatment of spasticity associated with multiple sclerosis.

    Adv Alcohol Subst Abuse. Nabilone in the treatment of multiple sclerosis. Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. Treatment of human spasticity with deltatetrahydrocannabinol. The effect of orally and rectally administered delta 9-tetrahydrocannabinol on spasticity: Int J Clin Pharmacol Ther. Tremor in multiple sclerosis. Safety, tolerability, and efficacy of orally administered cannabinoids in MS.

    Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers. Tetrahydrocannabinol for tremor in multiple sclerosis. The effect of cannabis on tremor in patients with multiple sclerosis. Suppression of pendular nystagmus by smoking cannabis in a patient with multiple sclerosis. The effect of cannabis on urge incontinence in patients with multiple sclerosis: Curr Opin Investig Drugs.

    Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on patients. Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis.

    Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis CAMS study: Cannabinoids in multiple sclerosis CAMS study: J Neurol Neurosurg Psychiatry. From anecdotal evidence of cannabinoids in multiple sclerosis to emerging new therapeutical approaches. Cannabinoids in MS - are we any closer to knowing how best to use them? The endocannabinoid pathway in Huntington's disease: Cannabinoid system and neuroinflammation: Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Neuroprotective cannabinoid receptor antagonist SRA prevents downregulation of excitotoxic NMDA receptors in the ischemic penumbra.

    Dexanabinol HU in the treatment of severe closed head injury: Efficacy and safety of dexanabinol in severe traumatic brain injury: Cannabinoid-based drugs as anti-inflammatory therapeutics. Anti-inflammatory property of the cannabinoid agonist WIN in a rodent model of chronic brain inflammation. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice. Involvement of the cannabimimetic compound, N-palmitoyl-ethanoIamine, in inflammatory and neuropathic conditions: Review of the available pre-clinical data, and first human studies.

    Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption. Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats. CB1 cannabinoid receptor signalling in Parkinson's disease.

    The cannabinoid receptor agonist WIN 55, reduces D2, but not D1, dopamine receptor-mediated alleviation of akinesia in the reserpine-treated rat model of Parkinson's disease. Effects of levodopa on endocannabinoid levels in rat basal ganglia: Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease.

    High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients. Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models.

    Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: DeIta9-tetrahydrocannabinol improves motor control in a patient with musician's dystonia. Cannabis for dyskinesia in Parkinson disease: Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia.

    Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson disease. Survey on cannabis use in Parkinson's disease: AIsasua del Valle A. Implication of cannabinoids in neurological diseases.

    An overview of Parkinson's disease and the cannabinoid system and possible benefits of cannabinoid-based treatments. Potential role of cannabinoids in Parkinson's disease.

    The pattern of neurodegeneration in Huntington's disease: Selective vulnerability in Huntington's disease: Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.

    Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease. The cannabinoid receptor agonist WIN 55, attenuates the effects induced by quinolinic acid in the rat striatum. Controlled clinical trial of cannabidiol in Huntington's disease. Cannabinoids reduce symptoms of Tourette's syndrome.

    Delta 9-tetrahydrocannabinol THC is effective in the treatment of tics in Tourette syndrome: Tourette syndrome is not caused by mutations in the central cannabinoid receptor CNR1 gene. Marijuana in the management of amyotrophic lateral sclerosis. Am J Hosp Palliat Care. Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice.

    AM , a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. The CB2 cannabinoid agonist AM prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset. Survey of cannabis use in patients with amyotrophic lateral sclerosis. A molecular link between the active component of marijuana and Alzheimer's disease pathology.

    Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. Int J Geriatr Psychiatry. DeItatetrahydrocannabinol for nighttime agitation in severe dementia. Anticonvulsant activity of four oxygenated cannabidiol derivatives. Res Commun Chem Pathol Pharmacol. Antiepileptic potential of cannabidiol analogs. Structure-anticonvulsant activity relationships of cannabidiol analogs.

    Anticonvulsant effect of cannabidiol. S Afr Med J. Cannabidiol-antiepileptic drug comparisons and interactions in experimentally induced seizures in rats. Anticonvulsant interaction of cannabidiol and ethosuximide in rats. Potential therapeutical effects of cannabidiol in children with pharmacoresistant epilepsy. Cannabinoid CB1 receptor antagonists cause status epilepticus-Iike activity in the hippocampal neuronal culture model of acquired epilepsy.

    Arachidonyl-2'-chIoroethyIamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model. Grand mal convulsions subsequent to marijuana use. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Cannabidiol CBD can help treat seizures, can reduce anxiety and paranoia, and can counteract the "high" caused by THC.

    Different cultivars strains or types and even different crops of marijuana plants can have varying amounts of these and other active compounds. This means that marijuana can have different effects based on the strain used. A number of small studies of smoked marijuana found that it can be helpful in treating nausea and vomiting from cancer chemotherapy.

    A few studies have found that inhaled smoked or vaporized marijuana can be helpful treatment of neuropathic pain pain caused by damaged nerves. Studies have long shown that people who took marijuana extracts in clinical trials tended to need less pain medicine. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer. There have been some early clinical trials of cannabinoids in treating cancer in humans and more studies are planned.

    While the studies so far have shown that cannabinoids can be safe in treating cancer, they do not show that they help control or cure the disease. Relying on marijuana alone as treatment while avoiding or delaying conventional medical care for cancer may have serious health consequences. Marijuana can also pose some harms to users. Smoked marijuana delivers THC and other cannabinoids to the body, but it also delivers harmful substances to users and those close by, including many of the same substances found in tobacco smoke.

    The effects can also differ based on how deeply and for how long the user inhales. Likewise, the effects of ingesting marijuana orally can vary between people. Also, some chronic users can develop an unhealthy dependence on marijuana. There are 2 chemically pure drugs based on marijuana compounds that have been approved in the US for medical use. Nabiximols is a cannabinoid drug still under study in the US. Based on a number of studies, dronabinol can be helpful for reducing nausea and vomiting linked to chemotherapy.

    Dronabinol has also been found to help improve food intake and prevent weight loss in patients with HIV. Research is still being done on this drug. Like many other drugs, the prescription cannabinoids, dronabinol and nabilone, can cause side effects and complications. Some people have trouble with increased heart rate, decreased blood pressure especially when standing up , dizziness or lightheadedness, and fainting.

    They can also worsen depression, mania, or other mental illness. Some patients taking nabilone in studies reported hallucinations. The drugs may increase some effects of sedatives, sleeping pills, or alcohol, such as sleepiness and poor coordination.

    Patients have also reported problems with dry mouth and trouble with recent memory. People who have had emotional illnesses, paranoia, or hallucinations may find their symptoms are worse when taking cannabinoid drugs. Talk to your doctor about what you should expect when taking one of these drugs.

    The American Cancer Society supports the need for more scientific research on cannabinoids for cancer patients, and recognizes the need for better and more effective therapies that can overcome the often debilitating side effects of cancer and its treatment. The Society also believes that the classification of marijuana as a Schedule I controlled substance by the US Drug Enforcement Administration imposes numerous conditions on researchers and deters scientific study of cannabinoids.

    Federal officials should examine options consistent with federal law for enabling more scientific study on marijuana. The American Cancer Society medical and editorial content team.

    Our team is made up of doctors and master's-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing. Cannabis in painful HIV-associated sensory neuropathy: Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.

    American College of Physicians. Supporting research into the therapeutic role of marijuana. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.

    J Pain Symptom Manage. Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. Comparison of orally administered cannabis extract and deltatetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: Smoked medicinal cannabis for neuropathic pain in HIV: A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.

    Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood,and sleep. J Acquir Immune Defic Syndr.

    Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med. Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:

    8 Medical Conditions That CBD Can Help Treat

    Jul 27, Cannabidiol (CBD) may have some health benefits, and it may also pose . The authors noted that current treatments for these disorders can. The FDA recently approved Epidiolex, which is made from CBD, as a therapy for people with very severe or hard-to-treat seizures. In studies, some people had a. Dec 15, But some medical marijuana is specially grown to have less of the Other conditions it might treat are Alzheimer's disease, Parkinson's.

    Explore Everyday Health



    Comments

    n125612n

    Jul 27, Cannabidiol (CBD) may have some health benefits, and it may also pose . The authors noted that current treatments for these disorders can.

    Modaaa

    The FDA recently approved Epidiolex, which is made from CBD, as a therapy for people with very severe or hard-to-treat seizures. In studies, some people had a.

    marat18061987

    Dec 15, But some medical marijuana is specially grown to have less of the Other conditions it might treat are Alzheimer's disease, Parkinson's.

    fred323

    Feb 26, Cannabidiol is a popular natural remedy used for many common ailments. common mental health disorders that can have devastating impacts on health Some test-tube and animal studies have even shown that CBD may.

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