Any relevant reports that have been included in the areas below have been culled from PubMed, an online service of the U.S. National Library of Medicine. Cannabis sativa L. preparations have been used in medicine for millenia. Numerous diseases, such as anorexia, emesis, pain, inflammation, multiple . There are some negative effects of cannabis use other than addiction, most of . can also be treated with cannabis extracts containing THC, or CBD, or with Sativex. Jan 3, 8 Medical Conditions That CBD Can Help Treat in recent years concerning CBD's medical usefulness, including some diseases and ailments.
the can treated by Some are: CBD conditions be of that
Since then cannabinoids were found to act on various cancer cell lines, through various mechanisms. Moreover, cannabinoid challenge decreased the efficiency of glioma stem-like cells to initiate glioma formation in vivo.
Activation of these receptors decreased growth, proliferation, angiogenesis, and metastasis, and increased apoptosis, of melanomas in mice. These effects were prevented by blockade of the CB2 cannabinoid receptor or by pharmacologic inhibition of ceramide synthesis de novo. THC inhibited tumor-cell proliferation in vitro, decreased tumor-cell Ki67 immunostaining and prolonged the survival time of two of the patients.
Many drugs used today can cause addiction and are misused and abused, for example opiates, cocaine, benzodiazepines, barbiturates, cholinergic agonists, ketamine, , dopaminergic agonists, amphetamines, and others. Nevertheless they are still an important part of our pharmacopeia.
Marijuana was used for centuries as a medicinal plant, but during the last century, because of its abuse and addictive potential it was taken out of clinical practice. Now, we believe that its constituents and related compounds should be brought back to clinical use.
The endocannabinoid system is a very complex one and regulates numerous processes, in parallel with other wellknown systems, such as the adrenergic, cholinergic, and dopaminergic systems. National Center for Biotechnology Information , U. Journal List Dialogues Clin Neurosci v. Kogan , MSc Natalya M. Author information Copyright and License information Disclaimer. This is an open-access article distributed under the terms of the Creative Commons Attribution License http: This article has been cited by other articles in PMC.
Abstract Cannabis sativa L. Abstract Las preparaciones de Cannabis sativa L. Addiction to canabis, and the influence of cannabis on addiction to other substances Marijuana may produce mild dependence in humans. Negative effects of cannabis other than addiction There are some negative effects of cannabis use other than addiction, most of them related to alterations of attentional and cognitive functions or other neuropsychological and behavioral effects.
Therapeutic uses of cannabinoids Obesity, anorexia, emesis Cannabis has been known for centuries to increase appetite and food consumption. Pain Cannabis has been used for millennia as a pain-relieving substance. Multiple sclerosis, neuroprotection, inflammation Inflammation, autoimmune response, demyelination, and axonal damage are thought to participate in the pathogenesis of MS.
Parkinson's disease, Huntington's disease, Tourette's syndrome, Alzheimer's disease, epilepsy Parkinson's disease PD is a chronic, progressive neurodegenerative disorder. Bipolar disorder, schizophrenia, post-traumatic stress disorder PTSD , depression, anxiety, insomnia Cannabis use is common in patients with bipolar disorder, and anecdotal reports suggest that some patients use marijuana to alleviate symptoms of both mania and depression.
Asthma, cardiovascular disorders, glaucoma Asthma is a chronic disease of the respiratory system in which the airway occasionally constricts, becomes inflamed, and is lined with excessive amounts of mucus. Cancer The antiproliferative action of cannabinoids on cancer cells was first noticed in the s.
Conclusion Many drugs used today can cause addiction and are misused and abused, for example opiates, cocaine, benzodiazepines, barbiturates, cholinergic agonists, ketamine, , dopaminergic agonists, amphetamines, and others. Early medical use of cannabis.
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Rimonabant improves cardiometabolic risk profile in obese or overweight subjects: Rimonabant in obese patients with type 2 diabetes. Am J Health Syst Pharm. Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia.
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Different cultivars strains or types and even different crops of marijuana plants can have varying amounts of these and other active compounds. This means that marijuana can have different effects based on the strain used. A number of small studies of smoked marijuana found that it can be helpful in treating nausea and vomiting from cancer chemotherapy.
A few studies have found that inhaled smoked or vaporized marijuana can be helpful treatment of neuropathic pain pain caused by damaged nerves. Studies have long shown that people who took marijuana extracts in clinical trials tended to need less pain medicine. Some animal studies also suggest certain cannabinoids may slow growth and reduce spread of some forms of cancer. There have been some early clinical trials of cannabinoids in treating cancer in humans and more studies are planned.
While the studies so far have shown that cannabinoids can be safe in treating cancer, they do not show that they help control or cure the disease. Relying on marijuana alone as treatment while avoiding or delaying conventional medical care for cancer may have serious health consequences. Marijuana can also pose some harms to users. Smoked marijuana delivers THC and other cannabinoids to the body, but it also delivers harmful substances to users and those close by, including many of the same substances found in tobacco smoke.
The effects can also differ based on how deeply and for how long the user inhales. Likewise, the effects of ingesting marijuana orally can vary between people. Also, some chronic users can develop an unhealthy dependence on marijuana. There are 2 chemically pure drugs based on marijuana compounds that have been approved in the US for medical use. Nabiximols is a cannabinoid drug still under study in the US. Based on a number of studies, dronabinol can be helpful for reducing nausea and vomiting linked to chemotherapy.
Dronabinol has also been found to help improve food intake and prevent weight loss in patients with HIV. Research is still being done on this drug. Like many other drugs, the prescription cannabinoids, dronabinol and nabilone, can cause side effects and complications. Some people have trouble with increased heart rate, decreased blood pressure especially when standing up , dizziness or lightheadedness, and fainting.
They can also worsen depression, mania, or other mental illness. Some patients taking nabilone in studies reported hallucinations. The drugs may increase some effects of sedatives, sleeping pills, or alcohol, such as sleepiness and poor coordination.
Patients have also reported problems with dry mouth and trouble with recent memory. People who have had emotional illnesses, paranoia, or hallucinations may find their symptoms are worse when taking cannabinoid drugs. Talk to your doctor about what you should expect when taking one of these drugs.
The American Cancer Society supports the need for more scientific research on cannabinoids for cancer patients, and recognizes the need for better and more effective therapies that can overcome the often debilitating side effects of cancer and its treatment. The Society also believes that the classification of marijuana as a Schedule I controlled substance by the US Drug Enforcement Administration imposes numerous conditions on researchers and deters scientific study of cannabinoids.
Federal officials should examine options consistent with federal law for enabling more scientific study on marijuana. The American Cancer Society medical and editorial content team.
Our team is made up of doctors and master's-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing. Cannabis in painful HIV-associated sensory neuropathy: Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.
American College of Physicians. Supporting research into the therapeutic role of marijuana. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.
J Pain Symptom Manage. Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. Comparison of orally administered cannabis extract and deltatetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: Smoked medicinal cannabis for neuropathic pain in HIV: A pilot clinical study of Delta9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
Dronabinol and marijuana in HIV-positive marijuana smokers. Caloric intake, mood,and sleep. J Acquir Immune Defic Syndr.
Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. N Engl J Med. Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:
8 Medical Conditions That CBD Can Help Treat
Jul 27, Cannabidiol (CBD) may have some health benefits, and it may also pose . The authors noted that current treatments for these disorders can. The FDA recently approved Epidiolex, which is made from CBD, as a therapy for people with very severe or hard-to-treat seizures. In studies, some people had a. Dec 15, But some medical marijuana is specially grown to have less of the Other conditions it might treat are Alzheimer's disease, Parkinson's.