The trend towards the legalization of marijuana and the increasing use of this herbal product and its oils (CBD) for both recreational and. Home» Term» cbd oil What Are the Symptoms of Estrogen Dominance? under Women's Bodies · How to Become Your Own Valentine under Emotional. J Pharmacol Exp Ther. Feb;(2) Marijuana: interaction with the estrogen receptor. Sauer MA, Rifka SM, Hawks RL, Cutler GB Jr, Loriaux DL.
and Estrogen CBD
The CB2 receptors are predominantly found in peripheral tissues and in cells of the immune system. The CB1 receptors are in the presynaptic neurons on the axon terminals. The endocannabinoids themselves are synthesized and released on demand by the postsynaptic neurons. When the receptors are bonded with the ligand endocannabinoids, the release of additional neurotransmitters by the presynaptic cell is blocked, thereby allowing regulation of neurotransmission of incoming signals.
FAAH, fatty acid amide hydrolase, is an enzyme which breakdowns anandamide and monoacylglycerol lipase breakdowns 2- AG, controlling quantities. FAAH is under the control of estradiol. The endocannabinoid system and estrogens have both direct and indirect interactions.
The endocannabinoid system impacts the release of estrogens through the central down-regulation of LH and GnRH. This is suggestive that as the pituitary gland remains sensitive to stimulation, the impact of cannabinoids is through its effects on central neurotransmission, suppressing LH release. It is complex and variable by brain region and even by synapses, but changes to the function of estrogen do influence central endocannabinoid signaling.
There is clearly a complex interrelationship between endocannabinoid activity and estradiol levels. It certainly appears that the use of an exogenous cannabinoid could adversely impact the hormonal cycling and fertility of females.
Here is a summary of what is currently known about the interrelationship of endocannabinoids and estrogen. Central CB1 receptor expression is modulated by estradiol and estradiol also increases anandamide synthesis while decreasing FAAH activity. FAAH is the principle enzyme which degrades the endocannabinoid anandamide.
Reductions in this degrading enzyme would, of course, increase the amount of the cannabinoid present. The consequence of these gonadotropin decreases is a decrease in the release of estrogen from the ovaries.
Estradiol also down-regulates FAAH activity peripherally in both the uterus and in immune cells. Endocannabinoid activity as well as CB1 receptor function fluctuates throughout the menstrual cycle. In humans, the amount of anandamide circulating is higher during the follicular phase and highest during ovulation, while being lower during the luteal phase.
It appears that the endocannabinoid system is significant in the regulation of the menstrual cycle and indeed does play a role in fertility. Various components of the endocannabinoid system have been found in the ovaries and uterus, and levels vary in a set manner during the time of embryo implantation.
Data suggests that low anandamide levels are a requirement for implantation and for carrying a pregnancy to term, while high levels of anandamide facilitates the labor process. In fact, it has been found that during pregnancy there are low levels of anandamide present and a surge occurs near the time of labor onset.
As well, with increased levels of anandamide or if an agonist of it is given results in early pregnancy, a higher rate of miscarriages in humans is seen. In rats which were ovariectomized and then given estradiol, there was an increase in the production of anandamide, showing that estradiol has a direct impact on its production as well as regulating its degradation.
In summary, though more complex than what will follow, as the two systems have multiple pathways of interconnectivity, it appears that estradiol modulates the receptor activity, the production, and the degradation of the endocannabinoids, both in the CNS and peripherally.
In turn, the endocannabinoids downregulate the production of estradiol by decreasing the release of gonadotropins. Estradiol administration in female rats elicits anxiolytic and antidepressant-like effects.
Studies show that the impact on emotions which are due to estradiol are elicited through the endocannabinoid system. Research on the emotional and behavioral effects involved in the interplay between the endocannabinoid system and estradiol show that estradiol incorporates the endocannabinoid system in its behavioral effects and can down-regulate FAAH activity in the CNS, thereby increasing the levels of anandamide.
Further confirming these findings are studies showing that when a CB1 receptor antagonist was given to rats, the anxiolytic effect of estradiol was blocked, and when a blocker of FAAH the enzyme which degrades anandamide was given, and levels of the endocannabinoid rose, and an anxiolytic effect occurred, precisely like that produced by estradiol.
Brain endocannabinoids have been recognized as major modulators of affect, motivation, and emotions, and the emerging connection to estradiol, and the other sex hormones, is only recently emerging and must now be recognized for their great significance in the functioning of this critical body system. With the recent recognition of the critical and complex bidirectional effects of the endocannabinoid system and the dominant female hormone — estradiol, and of the impact of marijuana and other cannabinoids, including the heightened susceptibility of women to their effects of dependency — we have entered a new era, a new future filled with many potential opportunities both for the benefit and for the detriment of women.
We must now begin our journey with the attainment of a solid knowledge-base of the endocannabinoid system, and an understanding of its complex role in reproductive, emotional, and immune health in women. This sick cycle is perpetuated by the hormone known as cortisol. Our body creates cortisol whenever we are in a situation that we perceive as stressful.
So, if the job, kids, and bills are all causing you stress day in and day out, you are probably in a constant case of panic. Each time we feel that way, our body pumps out more cortisol. That means no serotonin, so we feel depressed. That means no estrogen, so we feel off-kilter. Too much cortisol ruins everything.
Thankfully, CBD oil combats cortisol. It does this by stimulating the CB1 receptor. When this happens, our brain signals a sedative-like effect. Therefore, no cortisol is created. In the absence of cortisol, we are free to create more of the aforementioned hormones and neurotransmitters. For instance, melatonin is the hormone that makes us sleepy. When cortisol is reigning supreme in our system, it wears out our adrenal glands.
After all, a big portion of the adrenal system, the adrenal cortex is where cortisol is created. If the adrenal glands run into overdrive, then it perpetuates many symptoms that coincide with an estrogen imbalance. For instance, if you are suffering from adrenal fatigue, your body exhibits symptom such as: When adrenal fatigue happens, beneficial hormones become comprised. Therefore, cortisol is prone to rear its ugly head again and throw the whole endocrine system off-balance.
As we mentioned before, diabetes may be a cause of estrogen imbalances. The endocrine system is responsible for many things, including overseeing our metabolism. This is done by producing hormones throughout the pancreas such as glucagon, somatostatin, and insulin.
Anyone familiar with insulin knows that this hormone plays an important role in diabetes management. This hormone helps our bodies not only absorb nutrients from food, but store them for later use. When insulin levels are off, it can result in two major causes of estrogen imbalance, hyperglycemia high blood sugar and hypoglycemia low blood sugar. CBD oil interacts directly with cannabinoid receptors inside the pancreas. This causes the body to produce the correct amount of insulin to maintain healthy blood sugar levels.
If blood sugar levels stay in check, estrogen levels should be soon to follow. CBD oil is an all-natural way to bring balance to your system. You get all the healing effects of the cannabinoid without worrying about feeling high.
The Endocannabinoid System and Estrogen
Marijuana smoke also contains apigenin, an estrogenic compound that can mess with your hormones, although CBD and THC themselves don't seem to be. Triple negative: These breast cancers do not have estrogen or progesterone ER+ or triple-positive breast cancer do better with lower ratios of THC to CBD—a . Cannabidiol (CBD) affects the body in many different ways. In this article, we explore how CBD affects our hormones and endocrine system.