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Here are the in words instructions for the Lunapic edit that looks for malignancy Upload a picture to Lunapic. Any purple in picture is dangerous Purple indicates presence of Phosphorus Malignancy It also sees areas of congestion Here is how to do Pixlr.
You can see different things in Pixlr, when you get to the last step called Color Lookup by clicking each different Color choice Check it out to get an idea The one I chose seemed to show the most, but flipping through the other Color choices gives you an idea of what is happening under the skin Now that I have an iPhone that is up to date, I do many of the edits on it If you download the free Puffin app from the iTunes store on your iPhone , it allows you to go to flash websites So you can do all 3 edits on the iPhone Photo goes into Photos library The autistic children got severely worse I realize their gobbledygook sounds very intelligent, but please, people have had their tumours double in size from this stuff Yogurt, cow breast milk, really?
You all should know better This is what cancer feeds on Considering how many sick people were swindled out of their savings it is no wonder things have happened to those who made it , sold it, or recommended it You have got to be kidding me!
Any other supplements like 4LifeTransfer Factor which contains colostrum as well as eggs, are also a big NO! I don't use so much copper strapping anymore You can see how the wings ended up flopping too in the finished piece But the wings do move or adjust to temperature differences, you will note the pictures look different Dog likes "Essence of Bee" too Thanks to Nick Nicholson Ferrocement Instructor for teaching me that elegance can occur in cement!
I also dropped the white silicate sand because though it makes it stronger it does make it heavier Ok that is a value judgement My mother owns a wine agency called Lorac Wine inc. This one came out too droopy. In the beginning, before I put the Plasti-Dip rubber into the plastic tubing to hug around the mechanical aspect of the left hand Demo of the two finger prosthetic-video above This time I am going to cover this armature in black Plasti-Dip, a flexible rubber coating that will still allow the joints to move I really don't know if I will be able to make prosthetics that can be usable, but I figure it doesn't hurt to try, right?
Sari's Homemade marble recipe: On top of no-weld armature: I cooked the piece later in the oven on low, which made the marble set better On top of a no weld armature design that I came up with 'cause Joseph wouldn't let me weld Also marble is heavy But I left the break because it shows how an integral steel armature keeps marble from shattering It is an important difference when a sculpture has an internal armature that is solid Covered in a real gold powder mixed with latex adhesive milk, brushed in al fresco while marble was soft still I found out, while trying to repair the crack, that cooking the marble turns it into sort of porcelain So it seems that porcelain is really just cooked marble Never would have discovered this if the marble hadn't gotten dropped Ok so Powdered resin means powdered glue You can actually use liquid glue too Liquid glue is way easier to find in stores!
Aragonite sand is calcium carbonate sand-you get this at pet stores, I got mine from Petsmart in the reptile section Aragonite is a form of marble, so Aragonite sand is basically marble dust But buying a bag of marble dust is really not easy at all The alkaline resistant glass fibres are another strange beast You can find these either at a sculptor supply house or from a company that specializes in cement supplies The glass fibres really help your marble hold together better, even just while you are applying it It really is worth finding It makes your sculpture a million times stronger M, that is a question I ask myself all the time Myself, I started with traditional materials My mother stuck me in a ceramics lab at a local Y when I was just a dumpling There were real potters there Colour is hard to guess But it is a good learning ground for touch That stays with you Years later I wanted to be more serious Carving like that is very robust, very physical But wow you have to sand things Sanding takes like months I didn't like the sanding part Some more years later a product called Winterstone came out It is basically a concrete type powder you mix with water You build like a frame, am armature, then put mesh on that, then cover that mesh with the Winterstone It comes ready to go This was more flexible for me Found out they call this "Ferrocement" It is another "accepted" medium Then I decided to use my knowledge to make marble instead of cement Cultured marble is also accepted But my husband thought my armatures were so cool he said I should leave them bare No marble or cement But I wanted colour so I started knotting coloured rope onto the frames I think possibly this is how that progression works I am actually careful about perceptions that way I like to be original but not so much that it is just weird Polymer clay is really really cool to work with if you want to make prosthetics or miniatures But yes, some artists are snobby about polymer- it is a niche group Two part epoxies like Apoxie Sculpt are very much like Winterstone- a concrete type material I love that stuff too!
A little pricey for a large work Blowing glass is HARD Wood is a niche too-I feel guilty about using wood so didn't really go there Made a cheese board once Alot of sanding too Bronze is a million dollars You work in wax then often someone else casts for you Then artists snob out that you didn't pour the bronze yourself Read More about the Spare hand I am starting again, again New magnetic spare hand A spare hand project, some of the prototypes Thanks to Gwylym Owen iliteratepoet on twitter for helping me come to the newer lighter more simplistic spare hand design Gwylym spent many hours researching prosthetic hands for me, which helped me to coalesce the concepts The key is the copper strapping, it bends My invention because Joseph wouldn't let me weld Here is an example of welded steel sculpture Vaccine will be Selenium Needle will contain Oxygen.
Since Molybdenum is antagonized by Boron, Boron should help people with Non verbal learning disorders Here is a study that showed higher Molybdenum levels in people with Learning Disorders They believe it is caused by Molybdenum in the fertilizers High Molybdenum is linked to low Copper Boron, which I mentioned earlier is an antagonist to Molybdenum is actually in the Copper family, but just way stronger Minus means they are detox type elements Plus means they are repair type elements Cottage Cheese is a Phosphorus primarily So if you eat Flaxseed oil mixed with cottage cheese, which is a component of the Budwig diet, then you are getting this formula: Manganese -2 Carbon -5 Cottage cheese Plus So eating flaxseed oil with cottage cheese actually detoxes you more than it feeds you!
So that is healthy You can see this in our editing method here Cottage cheese, theoretically, according to Dr. Budwig, changes biochemically when mixed with flaxseed oil That detox value of Minus 3 total would be similar to just ingesting a Titanium like hulled hemp seeds If the cottage cheese is indeed changed by the flaxseed oil, we should not be seeing Phosphorus buildup in people doing the Budwig diet Which says to me that the cottage cheese is still acting like cottage cheese in the body Which says to me that it is dangerous If your body is full of Phosphorus in your Spleen , Salmonella will more readily hop into your mouth A 30 day antiparasitic cocktail like Humaworm http: But if you are eating cottage cheese at the same time, that may take longer or be much much harder to do My two cents worth On the other hand, the rest of the diet Budwig seems nice The Bill Henderson protocol seems nice too So maybe the use of cottage cheese is mitigated by the lack of other things like red meat or ice cream or doughnuts Sari Grove how long ago did they diagnose?
Sari Grove Send me a picture of his right lung where the tumour is supposed to be If you have not already Start pancreatic enzymes immediately with raw garlic, cayenne pepper, black pepper, cruciferous vegetable diet, selenium These are selenium family on my chart which lower blood sugar fast Choose highest dosages that can be tolerated To the point of hypoglycaemia Choose Moringa Oleifera powder Fluorine family on chart Dose that also to oral tolerance Liquids absorb faster than solids Dose with Oxygens- Ground apricot kernels at 2 per 10 lbs of body weight Hide in unsweetened applesauce for taste Cloves chew eat swallow organic Burn Frankincense Tears in bedroom area for fume This can be inhaled Eat Basil, Mint, Oregano, in large amount Eat hulled hemp seeds in large amount White willow bark can be drunk as tea or as supplement Topical application optional depending on what Rob Roy advises Get anything else Lee Ann recommends to get Start whichever program ships first arrives where you are first No delay- start any antiparasitics you can get your hands on today now!
Start the better stuff when they get there You will need about 10 bottles for 10 months This removes heavy metals, without screwing up the body like most chelators will Francis Licorice root extract is the best I know Another 10 bottles of that will last maybe 10 days Drink one whole bottle a day If that is too strong, lower dosage to ability to handle it It is in Ottawa, Ontario, Canada, so be prepared to wait for shipment Periwinkle is the base of Vinca based chemo Do same method with Periwinkle as with Licorice Everything Plus column No Either upload here, message it to me, or do the NIDI yourself See my blog for how http: Proxy remedies don't work as well as first person He needs to be the boss of things Get help from every single animal human plant friend wall internet you know Half of what people tell you could be wrong Sort through the muck He is the expert of his own body Do it yourself Cancer repair manual is about validating the person If they have not love they are nothing Don't be swayed by smarts without love This is Mercury family on chart Magnesium is its opposite in Minus column Exercise raises magnesium lowers Mercury Another reason for him to walk far this minute Hence the heavy metals Defense product Harsher chelators might be dangerous Horses crib- chew on fences The spirit of the law on our street, is that local traffic is allowed to drive when they need to drive , on their own street Just because they did not bother to put up another local traffic only sign going south, does that mean that the spirit of the law is dead?
Dealing with a traffic incident can be frustrating, but getting the right information is crucial. Fortunately, the attorneys you'll meet here have a lot of experience with this, and it would be my pleasure to match you with the best fit.
Have you consulted a lawyer yet? No I have not Please tell me everything you can about this issue so the Lawyer can help you best. Is there anything else the Lawyer should be aware of? I was not charged with anything I am still recovering This was January 13, I have been told I should sue the police While you're filling out that form, I'll tell the Lawyer about your situation and then connect you two.
Customer reply 22 Apr http: Be aware I had a contra coupe concussion From the blow to my eye Leon Solicitor and Notary Avg. Thank you for your question, and will do my best to assist you with your question. Please understand this is not legal advise Please understand this is not legal advice but a guide to assist you. You should report the police actions and if you have photos of your injuries send them in with the complaints.
The medical reports from the hospital will back up your injuries and any loss of income you should be compensated for as well. In relation to the signs etc you should raise this with the department of roads that deal with this and have this rectified. But you should definitely take the police to task and report them and if you have a claim the officers should also be sued.
Contact your local solicitor that practices in Criminal Law and have them give you more details advice. I hope this makes sense and is of assistance.
If there is nothing further thank you for using my services. If I have missed anything, or you have any further questions please let me know If there is anything else in the future please do not hesitate to ask. Please do not forget to leave positive feedback. Regards Leon " GroveCanada. I didn't see the very tiny "Pitch" button at the bottom of the screen at the far right For me the email instructions were not specific enough about where the request a Pitch car button was I didn't understand that there was one more specific button that would appear Might be because a police officer punched me in the eye in january Police brutality has a way of messing with your eyesight sometimes apparently They were mad because I reversed when I saw their money trap They have been charging local traffic too When I saw them trying to trap me, I reversed my car Knowing they were illegal I was in hospital 3 weeks They said I was nuts Which is why I am taking Ubers now If I see them again, it is probably safer for me not to be driving I don't take kindly to corrupt policemen Was stopped by a police officer Who was looking for non- local traffic On my home street They were looking for a kill Handcuffed so tight to cut off circulation to my heart Punched in the eye so hard have been in hospital since then Will get out Wednesday Email to a friend Thursday February 4th, Still a little groggy from the medicines they gave me Reversed into the S.
This is all because they thought between am cars are not allowed to drive on their own street The law is actually Local Traffic only, but they obviously didn't bother to check Literally screaming at me through the window of my car So I went to the S. They pinned me to the ground as I yelled: One on top of me, the other handcuffs me so tight it cuts off all circulation to my heart I realize these guys are just hungry for a kill Then, they handcuff me, both hands This is Division 13 cops Then a bunch of police come from 42 division One female officer arrives I think from 52 division Then they re-handcuff me even tighter behind my back Go through my purse Find out I am totally legal all the way around Drive me to St.
Deleting files on their computer I think maybe there were video files or recordings, but I saw them delete while they were driving me They also turned off camera on my face in backseat-damage was so bad to my eye How does one call the police on the police? What is interesting is one officer smelled of marijuana when he touched me Titanium element causing schizophrenia-used extensively by strippers to forget their "Johns" The other officer smelled of Ecstacy-he jumped on top of me in the missionary position- go figure Heroin element that is snorted with Cocaine in lapdance clubs Which is why these clubs continue to operate in Toronto so called "legally" It is called GHB the date rape drug when it is in a drink The Heroin in the Cocaine or in the air or just by skin contact with a whore, is enough to cause Contact skin transmission by Reverse Osmosis Yes, just by touching an exotic dancer you are doing drugs If you touch an exotic dancer, you are now on drugs too The criminal element in adult entertainment clubs is rampant Jail is just another note on most peoples resumes there It involves the principle of: You swallow a pill that is high in Oxygen The pill travels to your tumour location I do use sound though Our tv set is sometimes set to Channel which is Spa music for our cats when we leave the condo So soundwaves are a part of our life a little already Essential oil Aromatherapy Treatment I put alot on actually to accomplish this faster Add Minus five to Minus seven, you get Minus Twelve So the Number system in the picture seems to work chemically too!
See how the numbers work? MS is associated with Lead poisoning so a heavy metal detox would be useful MS responds to high dose Vitamin D3, vitamin C, sunshine, fruit diets, light therapy, even tanning beds Ginger root, Galangal ginger family , Ginseng One of the things I noticed was I didn't get to see my own pictures I noticed that my opinion about just about anything was not interesting for anybody So last year I opted out of all the bullsh-t I figured out a way to take my own pictures I figured out a way to alter the course of the path of my dumb lump A the end of Book 3 of my series, I discovered how to turn a malignant lump to a benign lump NOT how to get rid of the lump itself, but how to change its chemistry Once I figured out how to disarm the grenade in my breast, I stopped worrying about eradicating the lump itself The whole size shrinkage dilemma thing I just wanted to kill the "mold" that could make it spread My theory was that Copper kills mold My brother helped me to choose a Copper thing that the body absorbs well We chose Licorice root When I started with Licorice root tincture I used St.
Francis , within maybe even 24 hours, my picture showed the lump surface was clearing I took Licorice root in some form or other for the whole year That was my biggest discovery Now I am just working on getting rid of a relatively safe benign lump I was told by a woman that she thinks Licorice root is estrogenic I even saw studies that said so much For the record about that-Licorice root is a Copper like Coffee or Tea Estrogens, like Phosphorus based things, like mold, like ejaculate sorry , are the total opposite to Copper I have no idea which scientists decided that Copper makes mold worse but they are wrong I have several blogs where I write down my thoughts about things, have been doing this for years, but this one is the newest information It's an 11 megabyte file in PDF format with about pages of posts So based on her diagnostics today of my brain, post-concussion January , I need to these are my ideas: Like Ginseng I have a Ginseng drink which is made locally Like Melatonin I have Dream Water which is a melatonin drink You do this Before getting a concussion!
Here are my results post-concussion: I was punched in the eye by a police officer longer story -so yes, obviously my visuals would be affected Apt Surgical Rotation App: Book 3 Grove Health Science Series Book 4 [Kindle Edition] Book V: This means you can even download them to your Kindle for iPhone, easily So if you click on the book covers that takes you to the Smashwords page for each book, where you can choose which format you need Here is our Scribd profile address https: These can also be read online easily Ok, so below are the books They are in reverse order So Book 8 of the Grove Health Science series is first By Sari Grove Price: Includes a Google translate into french version at back of book What are the effects one can expect?
Nonsurgical breast cancer lump removal protocol Book 5 of Grove Health Science Series Manuscript is updated as new information becomes available DIY Chemo for cancer Book 4 By Sari Grove Price: Oddball interviews about medical successes The pairing should be in the Minus Plus format This should straighten out some of the complexity of brain surgery for neurosurgeons Apt surgical rotation app By Sari Grove Series: Grove Health Sciences, Book 3.
Algae is one of the most pervasive things that grow in Nature This is Book 3 in the Grove Health Sciences series All this schooling takes time and if your website creation production can be busy and deadlines will be tight, expense get done. Yet, training is important to your website development business. I might suggest setting to start a date each month the moment training is finished. You know which will date it is actually each month to help you plan your production appropriately.
Make coming back your site designers to get together once a month and share their web page design knowledge and tips to they. Web design techniques are advancing constantly and web designers can find whole over the internet libraries filled with the latest methods.
Encourage the web design group to go via the internet, learn the most current web design trends and provide a set up having a date, time and place for that regular teaching to take place. Many think that the web site design industry is actually a knowledge established business and I could not say it enough times to my staff. Quite definitely a business which can be knowledge structured depends intensely, if certainly not entirely in -yes, everything you know.
Today, more than ever, know-how is electrical power and this is very true of this web design market. So what sort of training is essential for a appear web design business company? Begin with the beginning. When you have decided to offer a comprehensive collection of web design expertise, you need web developers and web site designers.
Web developers are definitely the guys exactly who do the code — hard and boring stuff, unless you like this type of thing. Many web developers possess attended web development training courses although others contain taught themselves web design and coding.
Professionally, I locate the self-taught web developers even more creative and competent. So , to establish the web design organization, you need a couple of good programmers, whether they carry out php, asp or other web based development language.
You should also try some good web-site designers. First impressions matter and sell items. No matter how very good and good your code, you need a good web design, the suitable look and feel to draw your customers and get the revenue. True, some web designers are usually more gifted and talented than others. Although do remember to review and promote good internet designs along with your team. Selection way to improve your internal web design expertise than to go over some sophisticated web sites and pay attention to by observing.
Study every single line, each shape and color of the net design. Web site design is about specifics. Train the guys to consider details within a web design. The thickness of any border, the proper icons in the right place can make all the difference. Top quality training is yet another vital component of the training system. Develop an eye with respect to details. Consumers get incredibly nervous the moment their web-site is going live.
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While this sounds clear and simple, manage to survive underestimate teaching. All this teaching takes time of course, if your website development production is definitely busy and deadlines happen to be tight, you will not regret get done. Yet, training is vital to your web site design business. I recommend setting to start a date each month the moment training is completed.
You know which usually date it truly is each month so you can plan your production consequently. Make coming back your web designers to celebration once a month and share their website creation knowledge and tips to the team.
Web design tactics are progressing constantly and web designers will find whole via the internet libraries filled with the latest solutions. Encourage the web design crew to go on-line, learn the newest web design styles and provide a set up which has a date, time and place for the regular training to take place.
Many think that the web page design industry is actually a knowledge centered business and I could not state it enough times to my staff. Quite naturally a business which can be knowledge structured depends greatly, if not entirely on -yes, everything you know. Today, more than ever, expertise is electric power and this is particularly true of the web design industry. So what kind of training is needed for a appear web design business company?
Start out with the beginning. When you have decided to give you a comprehensive choice of web design companies, you need web-developers and web site designers. Various web developers contain attended web design training courses while many others contain taught themselves web design and coding. Professionally, I find the self-taught web developers even more creative and competent.
Therefore , to establish the web design business, you need a couple of good coders, whether they perform php, asp or various other web based programming language. You also need some good web site designers. First impressions count up and sell goods. No matter how good and bright your code, you need a great web design, the perfect look and feel to attract your customers and get the revenue. True, a few web designers are usually more gifted and talented than others.
Nevertheless do take the time to review and share good world wide web designs along with your team. Selection way to improve your internal web design skills than go over some well-designed web sites and pay attention to by watching. Study every line, every shape and color of the internet design. Web design is about particulars. Train the guys to watch out for details within a web design.
The thickness of your border, a good icons inside the right place will make all the difference. Quality training is another vital component of the training course. Develop a great eye for the purpose of details. Consumers get incredibly nervous once their website is going live.
They believe the fact that the minute the net design is published online the whole world is usually scrutinizing this. So website development customers are incredibly intolerant to quality blemishes in a web development.
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However, training is vital to your web design business. I recommend setting a date each month when training is performed. You know which date it is actually each month so you can plan your production accordingly. Make moment for your site designers to meet up once a month and share their web development knowledge and tips to they.
Web design approaches are advancing constantly and web designers will get whole via the internet libraries full of the latest assets. Encourage your web design workforce to go over the internet, learn the most recent web design fads and provide a set up using a date, some place for your regular schooling to take place. Many think that the webdesign industry is a knowledge structured business and I could not state it enough times to my group.
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Focus on the beginning. A large number of web developers possess attended webdevelopment training courses while many others have got taught themselves web design and coding. Really, I locate the self-taught web developers even more creative and competent. Let us say that the motivation there has to be to start with.
Therefore , to establish the web design business, you need a few good programmers, whether they carry out php, or net or different web based development language. You should also try some good web site designers. First impressions add up and sell products. No matter how good and wise your code, you need a good web design, the perfect look and feel to attract your customers and get the product sales. True, several web designers are definitely more gifted and talented than others. Yet do take time to review www.
What better way to enhance your internally web design abilities than to go over some sophisticated web sites and pay attention to by observing. Study each line, every single shape and color of the net design. Website creation is about particulars. Train your guys to watch out for details within a web design. The thickness of the border, the appropriate icons inside the right place could make all the difference.
Top quality training is another vital element of the training software. Develop an eye for details. Consumers get incredibly nervous once their internet site is going live. They believe the fact that minute the internet design is definitely published via the internet the whole world is normally scrutinizing that.
So web development customers are extremely intolerant to quality defects in a web development. Have a quality checklist and train the web designer to identify the obvious blunders like destroyed links, misspelling, misalignment in the web design.
Every web design is certainly complete, the net designer need to go over the web page with the register and tick each item on the web web page. While this sounds clear and simple, you can underestimate teaching. All this training takes time of course, if your web design production is normally busy and deadlines will be tight, you will not regret get done. But, training is important to your web design business. I would recommend setting to start a date each month once training is completed.
You know which will date it is each month to help you plan the production consequently. Make moment for your site designers to get together once a month and share their website creation knowledge and tips to they.
Web design techniques are progressing constantly and web designers can find whole on the net libraries filled with the latest solutions. Encourage your web design group to go over the internet, learn the latest web design trends and provide a set up which has a date, some place for that regular teaching to take place. Many think that the web site design industry is mostly a knowledge established business and I could not state it enough times to my crew.
Quite certainly a business which is knowledge primarily based depends heavily, if not really entirely about -yes, whatever you know. Today, more than ever, expertise is ability and this is specially true within the web design sector. Get started with the beginning. When you have decided to give you a comprehensive variety of web design providers, you need web developers and web site designers.
Many web developers currently have attended webdevelopment training courses although many others have taught themselves web design and coding. In person, I find the self-taught web developers even more creative and competent. Therefore , to establish your web design organization, you need a handful of good coders, whether they carry out php, or net or additional web based development language.
No matter how very good and sensible your code, you need a very good web design, a good look and feel to draw your customers and get the product sales. True, a lot of web designers tend to be gifted and talented than others.
Although do take time to review and share good net designs with the team. Selection way to boost your in house web design abilities than go over some practical web sites and learn by observing.
Web page design is about particulars. Train your guys to consider details in a web design. The thickness of an border, the best icons in the right place will make all the difference. Quality training is yet another vital component of the training method.
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Make coming back your site designers to meet up once a month and promote their web page design knowledge and tips to the team. Web design methods are progressing constantly and web designers can find whole via the internet libraries full of the latest resources. Encourage your web design team to go on-line, learn the latest web design fashion and provide a set up with a date, as well as place to get a regular training to take place.
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So what sort of training is needed for a sound web design organization company? Web developers are definitely the guys just who do the code — hard and laborous stuff, unless you like this sort of thing. Many web developers contain attended webdevelopment training courses although many others own taught themselves web design and coding. Privately, I get the self-taught web developers more creative and competent.
So , to establish your web design organization, you need a few good programmers, whether they do php, or net or various other web based encoding language. First impressions count and sell items. No matter how great and sensible your code, you need a great web design, the best look and feel to attract your customers and get the product sales.
True, several web designers are definitely gifted and talented than others. Although do take time to review and promote good internet designs together with your team. Selection way to enhance your internal web design skills than to debate some well-designed web sites and find out by observing.
Study every line, every single shape and color of the internet design. Webdesign is about information. Train your guys to search for details in a web design. The thickness of any border, the suitable icons in the right place can make all the difference. Top quality training is yet another vital component of the training software. Develop a great eye to get details.
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Quite obviously a business which can be knowledge centered depends closely, if not really entirely about -yes, whatever you know. Today, more than ever, know-how is electrical power and this is specially true on the web design sector. So what sort of training is required for a appear web design business company? Web developers are definitely the guys who all do the code — hard and tiresome stuff, unless you like this kind of thing. Various web developers experience attended web development training courses while many others possess taught themselves web design and coding.
I think, I locate the self-taught web developers more creative and competent. Shall we say that the motivation will there be to start with. So , to establish your web design business, you need a handful of good coders, whether they do php, or net or other web based coding language.
First impressions rely and sell goods. No matter how good and wise your code, you need a very good web design, the proper look and feel to draw your customers and get the product sales. True, several web designers will be more gifted and talented than others. But do take time to review and promote good internet designs with the team.
What better way to improve your internally web design abilities than go over some classy web sites and learn by watching. Study every single line, each shape and color of the internet design. Train your guys to watch out for details in a web design. The thickness of your border, an appropriate icons in the right place can make all the difference. Quality training is another vital element of the training system.
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Journal of Pain 9: Smoked cannabis for chronic neuropathic pain: Incorporating cannabinergic medicine topics into pain medicine education seems warranted and continuing clinical research and empiric treatment trials are appropriate. Investigators at the University of Milan reported in that the administration of single cannabinoids such as THC or CBD produce limited relief compared to the administration of plant extracts containing multiple cannabinoids, terpenes oils , and flavonoids pigments.
These results are very encouraging and merit further study. British Journal of Clinical Pharmacology Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain. Journal of Symptom Management Prescribing cannabis for harm reduction. Harm Reduction Journal 9: Charcot-Marie-Tooth disease CMT Hereditary Motor and Sensory Neuropathy HMSN As we are developing an increased understanding of the physiological function of cannabinoids it is becoming evident that they may be involved in the pathology of some diseases, particularly neurological disorders.
Cannabinoids may induce both growth and death in a number of cells, including neurons. In the central nervous system CNS , most of the experimental evidence indicates that cannabinoids may protect neurons from damage induced by toxic and traumatic insults. Diabetes Mellitus Diabetes mellitus is a group of autoimmune diseases characterised by defects in insulin secretion resulting in hyperglycemia an abnormally high concentration of glucose in the blood.
There are two primary types of diabetes. Individuals diagnosed with type 1 diabetes also known as juvenile diabetes are incapable of producing pancreatic insulin and must rely on insulin medication for survival. Individuals diagnosed with type 2 diabetes also known as adult onset diabetes produce inadequate amounts of insulin. Type 2 diabetes is a less serious condition that typically is controlled by diet.
Over time, diabetes can lead to blindness, kidney failure, nerve damage, hardening of the arteries and death.
The disease is the third leading cause of death in the United States after heart disease and cancer. Writing in the March issue of the American Journal of Pathology, researchers at the Medical College of Virginia reported that rats treated with CBD for periods of one to four weeks experienced significant protection from diabetic retinopathy.
Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases. Journal of Neuroimmunology Current Topics in Medicinal Chemistry American Journal of Pathology Cannabinoids block tactile allodynia in diabetic mice without attenuation of its antinociceptive effect.
International Immunopharmacology Italy 4: Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. Journal of the American College of Cardiology Dystonia Dystonia is a neurological movement disorder characterised by abnormal muscle tension and involuntary, painful muscle contractions.
A small number of case reports and preclinical studies investigating the use of cannabis and cannabinoids for symptoms of dystonia are referenced in the recent scientific literature. A dramatic response to inhaled cannabis in a woman with central thalamic pain and dystonia. The Journal of Pain and Symptom Management It would appear that additional, larger clinical trials are warranted to investigate the use of cannabis and cannabinoids for this indication.
Effects of pharmacological manipulations of cannabinoid receptors on severe dystonia in a genetic model of paroxysmal dyskinesia. European Journal of Pharmacology Open label evaluation of cannabidiol in dystonic movement disorders. International Journal of Neuroscience Fibromyalgia Fibromyalgia FM is a chronic pain syndrome of unknown etiology.
The disease is characterised by widespread musculoskeletal pain, fatigue and multiple tender points in the neck, spine, shoulders and hips. An estimated 3 to 6 million Americans are afflicted by fibromyalgia, which is often poorly controlled by standard pain medications. Investigators at the Institut de Recerca Hospital del Mar in Barcelona, Spain, assessed the associated benefits of cannabis in patients with fibromyalgia compared with FM patients who did not use the substance.
Survey of Australians using cannabis for medical purposes. Harm Reduction Journal 4: The medicinal use of cannabis in the UK: International Journal of Clinical Practice Medical use of cannabis: Grotenhermen and Russo Eds. Pharmacology, Toxicology, and Therapeutic Potential. Medical use of cannabis in the Netherlands. As a result, some experts have suggested that cannabinoids are potentially applicable for the treatment of chronic pain conditions such as fibromyalgia, and have theorized that the disease may be associated with an underlying clinical deficiency of the endocannabinoid system.
Cannabis use in patients with fibromyalgia: Cannabinoid analgesia as a potential new therapeutic option in the treatment of chronic pain. The Annals of Pharmacotherapy Analgesia through endogenous cannabinoids.
Clinical endocannabinoid deficiency CECD: Incontinence Urinary incontinence is defined as a loss of bladder control. More than one in ten Americans over age 65 is estimated to suffer from incontinence, particularly women. Several recent clinical trials indicate that cannabinoid therapy may reduce incidents of incontinence. A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms.
An open label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis. The effect of cannabis on urge incontinence in patients with multiple sclerosis: The International Urogynecology Journal Nature Clinical Practice Neurology 2: While some GI disorders may be controlled by diet and pharmaceutical medications, others are poorly moderated by conventional treatments.
Patients with these disorders frequently report using cannabis therapeutically. Preclinical studies demonstrate that activation of the CB 1 and CB2 cannabinoid receptors exert biological functions on the gastrointestinal tract. Cannabis use among patients with inflammatory bowel disease.
Gastrointestinal illness and cannabis use in a rural Canadian community. Journal of Psychoactive Drugs Ulcerative colitis and marijuana. Annals of Internal Medicine Endocannabinoids and the gastrointestinal tract. Journal of Endocrinological Investigation 29 Suppl: Cannabinoids and the gastrointestinal tract. Cannabinoids for gastrointestinal diseases: Expert Opinion on Investigational Drugs Cannabinoid receptor agonism inhibits transient lower esophageal sphincter relaxations and reflux in dogs.
The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract. Journal of Molecular Medicine Differential expression of cannabinoid receptors in the human colon: Participants in the trial also reported requiring fewer surgeries following their use of cannabis.
Journal of the Israeli Medical Association Cannabinoids and the digestive tract. Handbook of Experimental Pharmacology Trends in Pharmacological Sciences Gliomas Gliomas tumors in the brain are especially aggressive malignant forms of cancer, often resulting in the death of affected patients within one to two years following diagnosis.
There is no cure for gliomas and most available treatments provide only minor symptomatic relief. Oncogene 27, — published online 9 July Guzman et al. Inhibition of tumor angiogenesis by cannabinoids. Researchers also noted that THC selectively targeted malignant cells while ignoring healthy ones in a more profound manner than the synthetic alternative. In the first ever pilot clinical trial assessing the use of cannabinoids and GBM, investigators found that the intratumoral administration of THC was associated with reduced tumor cell proliferation in two of nine subjects.
Cannabinoids inhibit the vascular endothelial growth factor pathways in gliomas PDF. Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells. Journal of Neurooncology A combined preclinical therapy of cannabinoids and Temozolomide against glioma.
Molecular Cannabis Therapeutics British Journal of Cancer 95, — Cannabinoids as a potential new drug therapy for the treatment of gliomas. Expert Reviews of Neurotherapeutics 8: Expression of cannabinoid receptors and neurotrophins in human gliomas. They conducted a magnetic resonance imaging study that looked at THC the main active compound in [cannabis] and found that it reduced neuronal injury in rats. The results of this study provide evidence that the cannabinoid system can serve to protect the brain against neurodegeneration.
The Journal of Neuroscience, 1 September , 21 The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation. Molecular Cancer Therapeutics 6: Cannabinoid receptors as a novel target for the treatment of prostate cancer. The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: Di Marzo et al. Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
Journal of Clinical Investigation Molecular Cancer Research 4: Leukemia and Lymphoma Nature Reviews Cancer 3: Molecular Cancer Therapeutics 9: Some users of both find cannabis itself more effective. Thus an inhalation but, preferably not smoking cannabinoid drug delivery system would be advantageous for treating chemotherapy-induced nausea. Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells Archives of Pharmacal Research: Cannabinoids in pancreatic cancer: International Journal of Cancer Journal of the National Cancer Institute Cannabinoids inhibit cellular respiration of human oral cancer cells.
Growth inhibition by receptor activation. Cannabinoids for cancer treatment: Breast Cancer Invasion and metastasis of aggressive breast cancer cells are the final and fatal steps during cancer progression.
Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. They also demonstrated that CBD significantly reduces tumor mass.
THC-acid was assessed whether there is any advantage in using Cannabis extracts enriched in either cannabidiol or THC over pure cannabinoids. Results obtained in a panel of tumor cell lines clearly indicate that, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth. They determined that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis and impair tumor angiogenesis. The study provides strong evidence for the use of cannabinoid based therapies for the management of breast cancer.
Breast Cancer Res Treat. Published online before print May 25, , doi: Molecular Cancer , 9: PNAS July 7, vol. Lung Cancer Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressing lung cancers, which are often highly aggressive and resistant to chemotherapy. The study published in the journal Oncogene, by Harvard Medical School's Experimental Medicine Department determined that THC inhibits epithelial growth factor induced lung cancer cell migration.
Additionally, in in vivo studies in severe combined immunodeficient mice, there was significant inhibition of the subcutaneous tumor growth and lung metastasis of A cells in THC-treated animals as compared to vehicle-treated controls. They go on to state that THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers. Effects were confirmed in primary tumor cells from a lung cancer patient.
Overall, data indicated that cannabinoids decrease cancer cell invasiveness. They determined its effectiveness and suggested that it should be used for treatment against lung cancer cells.
Oncogene 27, — published online 9 July Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule Cancer Prev Res Phila. Prostate Cancer Prostate cancer is a global public health problem, and it is the most common cancer in men and the second cause for cancer-related death. Prostate cancer cells possess increased expression of both cannabinoid 1 and 2 receptors, and stimulation of these; results in a decrease in cell viability, increased apoptosis, and decreased androgen receptor expression and prostate-specific antigen excretion.
It would be of interest to conduct clinical studies utilising cannabinoids for patients with metastatic prostate cancer, taking advantage not only of its beneficial effects on prostate cancer but also of their analgesic properties for bone metastatic cancer pain.
The US National Library of Medicine outlined multiple studies proving the effectiveness of cannabis on prostate cancer. A study published in the US National Library of Medicine illustrates a decrease in prostatic cancer cells by acting through cannabinoid receptors. It was determined that cannabidiol significantly inhibited cell viability. Basic science perspective and potential clinical applications. PMC Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: It was investigated that the effect of THC on the upstream and downstream events modulates the extracellular signal-regulated kinase ERK module of mitogen-activated protein kinase pathways primarily in human Jurkat leukemia T cells.
These observations prompted the investigation into their effects on the mitochondrial O 2 consumption in human oral cancer cells Tu This epithelial cell line overexpresses bcl-2 and is highly resistant to anticancer drugs. Cannabinoids are potent inhibitors of cellular respiration and are toxic to highly malignant oral tumors.
When these tumors are in advanced stages, few therapeutic options are available. Therefore, it is essential to search for new treatments to fight this disease. Moreover, cannabinoids were also able to inhibit tumor growth and ascites in an orthotopic model of HCC xenograft.
The findings may contribute to the design of new therapeutic strategies for the management of HCC. Epub Jun 2. Epub Apr 8. Pancreatic Cancer Pancreatic adenocarcinomas are among the most malignant forms of cancer. A published study in The American Journal of Cancer undertook to investigate the action of cannabinoids, a new family of potential antitumoral agents, in pancreatic cancer. Cannabinoid receptors are expressed in human pancreatic tumor cell lines and tumor biopsies at much higher levels than in normal pancreatic tissue.
Cannabinoids also reduced the growth of tumor cells in two animal models of pancreatic cancer. In addition, cannabinoid treatment inhibited the spreading of pancreatic tumor cells.
Moreover, cannabinoid administration selectively increased apoptosis and TRB3 expression in pancreatic tumor cells but not in normal tissue. In conclusion, results presented show that cannabinoids lead to apoptosis of pancreatic tumor cells via a CB2 receptor and de novo synthesised ceramide-dependent up-regulation of p8 and the endoplasmic reticulum stress—related genes ATF-4 and TRB3.
These findings may contribute to set the basis for a new therapeutic approach for the treatment of pancreatic cancer. Hepatitis C Hepatitis C is a viral disease of the liver that afflicts an estimated four million Americans.
Chronic hepatitis C is typically associated with fatigue, depression, joint pain and liver impairment, including cirrhosis and liver cancer. Patients diagnosed with hepatitis C frequently report using cannabis to treat both symptoms of the disease as well as the nausea associated with antiviral therapy.
Preclinical data indicates that the endocannabinoid system may moderate aspects of chronic liver disease, and that cannabinoids may reduce inflammation in experimental models of hepatitis. Forschende Komplementarmedizin Germany 3: Cannabis use improves retention and virological outcomes in patients treated for hepatitis C. The endocannabinoid system in chronic liver disease. Annals of Hepatology 4: Endocannabinoids and liver disease — review.
A novel synthetic cannabinoid derivative inhibits inflammatory liver damage via negative cytokine regulation. Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis C. Influence of cannabis use on severity of hepatitis C disease. Clinical Gastroenterology and Hepatology 6: Role of cannabinoids in liver disease. World Journal of Gastroenterology Treatment for hepatitis C virus and cannabis use in illicit drug user patients: Role of cannabinoids in the development of fatty liver steatosis.
Its value as an antiemetic and analgesic has been proven in numerous studies and has been recognised by several comprehensive, government-sponsored reviews, including those conducted by the Institute of Medicine IOM , the U.
Cannabis use in HIV for pain and other medical symptoms. Journal of Pain Symptom Management Journal of Acquired Immune Deficiency Syndromes Journal of Cannabis Therapeutics 3: Drug and Alcohol Dependence Writing in the journal Neuropsychopharmacology, they concluded: Mood disturbance, physical disability and quality of life all improved significantly during study treatment. The findings suggest that cannabinoid therapy may be an effective option for pain relief in patients with medically intractable pain due to HIV.
Cannabinoid administration attenuates the progression of simian immunodeficiency virus. The federal obsession with a political agenda that keeps [cannabis] out of the hands of sick and dying people is appalling and irrational.
It stimulates the appetite and promotes weight gain, in turn strengthening the body, combating chronic fatigue, and providing the stamina and physical well-being necessary to endure or withstand both adverse side effects of ongoing treatment and other opportunistic infections. It has been shown effective in reducing nausea, neurological pain and anxiety, and in stimulating appetite.
When these symptoms are associated with or caused by other therapies, marijuana has been useful in facilitating compliance with more traditional therapies. It may also allow individual patients to engage in normal social interactions and avoid the despair and isolation which frequently accompanies long-term discomfort and illness. In my practice, [cannabis] has been of greatest benefit to patients with wasting syndrome. Likewise, for some of my patients undergoing chemotherapy, when conventional drugs fail to relieve the severe nausea and vomiting, I often find that marijuana provides the patient with the ability to eat and to tolerate aggressive cancer treatments.
Marinol is a form of THC, one of the key active components of marijuana; it is essentially a marijuana extract. Marcus Conant is a physician who has practiced medicine for 33 years in San Francisco.
In some cases, the reason is simple: Marinol is taken orally, in pill form. Patients suffering from severe nausea and retching cannot tolerate the pills and thus do not benefit from the drug.
There are likely other reasons why smoked marijuana is sometimes more effective than Marinol. The body's absorption of the chemical may be faster or more complete when inhaled. Means of ingestion is often critical in understanding treatment efficacy. The nausea, which can last for days, weeks or months, is one of the most severe forms of discomfort or pain that the human being can experience. It destroys the quality of life of the patient, whose sole objective is to make it through the next hour, the next day.
Racked by intense vomiting and queasiness, time for the patient seems to stand still. Wasting can take a similar psychological and physical toll.
If I am unable to relieve the patient's nausea with [conventional] remedies, I next prescribe Marinol, a synthetic version of THC, one of the main active compounds found in marijuana.
Marinol is also helpful in stimulating appetite in patients suffering from AIDS wasting, as are other drugs, Megace, anabolic steroids, and human growth hormone. I firmly believe that medical marijuana is medically appropriate as a drug of last resort for a small number of seriously ill patients. Over 20 years of clinical experience persuade me of this fact. The anecdotal evidence is overwhelming. Almost every patient I have known to have tried marijuana achieved relief from symptoms with it.
That success rate far surpasses that for Compazine. Accordingly, as with any other medication that I consider potentially beneficial to my patients, I must discuss the option of medical marijuana in detail when appropriate. Anything less is malpractice. Marijuana has Dr. He is the author of numerous articles and a member of many professional organizations. I have seen marijuana restore patients' will to live by restoring their ability to eat, gain strength, and perform simple, daily activities free from crippling nausea or pain.
There is no doubt in my mind that for some seriously ill patients, marijuana can help make the difference between life and death; and that for other terminally ill patients, marijuana can make the difference between exercising control over their final months and days and passing in relative peace and comfort, or dying in constant and severe agony or incapacitated in a prolonged sedated haze, unaware of their surroundings.
Marijuana, in short, can help sick and dying persons achieve autonomy over their lives by alleviating the intense suffering caused by their illnesses or the side effects of their medications. For some patients for example those suffering from operable cancer , medical marijuana may allow them to continue their treatments and thus serve as a bridge to eventual cure; for others marijuana may help promote relative well-being and prolong a life free from intolerable pain; and for still other patients, marijuana may help them control the manner and timing of their deaths consistent with their values, beliefs and dignity.
Referenced from Doctor experiences. Although the administration of cannabidiol in HD patients provided little symptomatic relief compared to placebo in a single clinical trial, more recent preclinical data indicates that cannabinoids may possess potential to moderate the advancement of the disease and similar neurodegenerative disorders. Pharmacology, Biochemistry, and Behavior Journal of Neuroscience Research Hypertension High blood pressure, or hypertension, afflicts an estimated one in four American adults.
This condition puts a strain on the heart and blood vessels and greatly increases the risk of stroke and heart disease. Emerging research indicates that the endogenous cannabinoid system plays a role in regulating blood pressure, though its mechanism of action is not well understood.
However, complete tolerance to these effects develops quickly and potential health risks appear minimal. Clinical pharmacodynamics of cannabinoids. Blood pressure regulation by endocannabinoids and their receptors PDF. Endocannabinoids and vascular function. Journal of Pharmacology and Experimental Therapeutics.
Endocannabinoids as cardiovascular modulators. Chemistry and Physics of Lipids Cardiovascular system effects of marijuana. Journal of Clinical Pharmacology. Cardiac and vascular effects of cannabinoids: Forensic Science, Medicine, and Pathology. Marijuana use, diet, body mass index and cardiovascular risk factors. American Journal of Cardiology Towards a therapeutic use of selective CB2 cannabinoid receptor ligands for atherosclerosis. Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice.
Cannabinoid receptors in atherosclerosis. Current Opinion in Lipidology Journal of the American Medical Association Antibacterial cannabinoids from cannabis sativa: Journal of Natural Products Multiple Sclerosis Multiple sclerosis MS is a chronic degenerative disease of the central nervous system that causes inflammation, muscular weakness and a loss of motor coordination.
Over time, MS patients typically become permanently disabled and, in some cases, the disease can be fatal. According to the US National Multiple Sclerosis Society, about people are diagnosed every week with the disease, often striking those 20 to 40 years of age. Writing in the July issue of the journal Brain, Chong et al. Cannabis use in patients with multiple sclerosis. Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: Cannabis use as described by people with multiple sclerosis [PDF].
Canadian Journal of Neurological Sciences The perceived effects of smoked cannabis on patients with multiple sclerosis. European Journal of Neurology Effects of cannabinoids on spasticity and ataxia in multiple sclerosis. Journal of Neurology Advances in Alcohol and Substance Abuse 7: Marijuana as a therapeutic agent for muscle spasm or spasticity.
Patterns of cannabis use among patients with multiple sclerosis. On average, patients in the study required fewer daily doses of the drug and reported lower median pain scores the longer they took it. In recent years, health regulators in Canada, Denmark, Germany, Spain and the United Kingdom have approved the prescription use of plant cannabis extracts to treat symptoms of multiple sclerosis.
Regulatory approval in the European Union and in the United States remains pending. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Immunomodulatory effects of orally administered cannabinoids in multiple sclerosis. Osteoporosis Osteoporosis is a degenerative skeletal disease characterised by a deterioration of bone tissue. Patients with osteoporosis are at risk for suffering multiple fractures and other serious disabilities.
Initial references regarding the potential use of cannabinoids to protect against the onset of osteoporosis are available in the scientific literature beginning in the early s. Casopis Lekaru Ceskych Czech Republic Peripheral cannabinoid receptor, CB2, regulates bone mass. Regulation of Skeletal Remodeling by the Endocannabinoid System.
Annals of the New York Academy of Sciences Cannabinoids and the skeleton: Annals of Medicine Phantom limb syndrome Patients who suffer amputation of an extremity can experience a type of referred neuropathic pain in the amputated zone. Pharmacologic management of this condition is complex and it is based mainly on anticonvulsants. The use of cannabinoids is supported by their efficacy in alleviating neuropathic pain. Promising results have been obtained in clinical practice.
Pruritus Itching pruritus is a common symptom associated with numerous skin diseases, as well as a secondary symptom of numerous serious conditions such as renal failure and liver disease. Itching, unlike other skin sensations, is generally a result of CNS activities and typically goes untreated by standard medical therapies. A review of the scientific literature reveals three clinical trials investigating the use of cannabinoids in the treatment of pruritus.
Writing in the August issue of the American Journal of Gastroentrology, investigators from the University of Miami Department of Medicine reported successful treatment of pruritus with 5 mg of THC in three patients with cholestatic liver disease. Resolution of depression was also reported in two out of three subjects.
Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease. American Journal of Gastroenterology Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin.
Efficacy and tolerance of the cream containing structured physiological lipid endocannabinoids in the treatment of uremic pruritus: Acta Dermatovenerologic Croatica Croatia
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